High-Mobility Group Box 1 Neutralization Prevents Chronic Cerebral Hypoperfusion-Induced Optic Tract Injuries in the White Matter Associated with Down-regulation of Inflammatory Responses
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00702-7
Abstract: Chronic cerebral hypoperfusion (CCH)-induced white matter lesions (WMLs) are region-specific with the optic tract (OT) displaying the most severe damages and leading to visual-based behavioral impairment. Previously we have demonstrated that anti-high-mobility group box 1… read more here.
Keywords: cerebral hypoperfusion; inflammatory responses; high mobility; optic tract ... See more keywords
Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57445-x
Abstract: Mechanisms underlying functional axonal rewiring after adult mammalian central nervous system (CNS) injuries remain unclear partially due to limited models. Here we develop a mouse intracranial pre–olivary pretectal nucleus (OPN) optic tract injury model and… read more here.
Keywords: presynaptic activity; cns injuries; optic tract; regeneration ... See more keywords
Evaluating the impact of denoising diffusion MRI data on tractometry metrics of optic tract abnormalities in glaucoma
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-10947-6
Abstract: Diffusion MRI (dMRI)-based tractometry is a non-invasive neuroimaging method for evaluating white matter tracts in living humans, capable of detecting abnormalities caused by disorders. However, measurement noise in dMRI data often compromises the signal quality.… read more here.
Keywords: tractometry metrics; tractometry; diffusion mri; impact ... See more keywords
Optic tract edema in craniopharyngioma as a predictor of BRAFV600E mutation presence.
Sign Up to like & getrecommendations! Published in 2023 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyad003
Abstract: OBJECTIVE the advent of BRAF inhibitors for preoperative treatment of craniopharyngioma has necessitated the identification of BRAFV600E status. Hence, we investigated predictors of BRAFV600E mutation in craniopharyngiomas. METHODS this retrospective study utilized data from 30… read more here.
Keywords: optic tract; mutation; tract edema; brafv600e mutation ... See more keywords
Vertebrobasilar Dolichoectasia Causing An Optic Tract Syndrome.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Ophthalmology"
DOI: 10.1097/wno.0000000000000495
Abstract: Vertebrobasilar dolichoectasia (VBD) is characterized by significant dilation, elongation, and tortuosity of the vertebrobasilar system. We present a unique case of VBD, confirmed by neuroimaging studies, showing vascular compression of the right optic tract and… read more here.
Keywords: causing optic; vertebrobasilar dolichoectasia; optic tract; dolichoectasia causing ... See more keywords
Cannabinoid Receptor Type 1 regulates growth cone filopodia and axon dispersion in the optic tract of Xenopus laevis tadpoles
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15603
Abstract: Previous studies show that the main cannabinoid receptor in the brain—cannabinoid type 1 receptor (CB1R)—is required for establishment of axonal projections in developing neurons but questions remain regarding the cellular and molecular mechanisms, especially in… read more here.
Keywords: optic tract; growth; growth cone; cone filopodia ... See more keywords
Chromatic processing and receptive-field structure in neurons of the anterior optic tract of the honeybee brain
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0310282
Abstract: Color vision in honeybees is a well-documented perceptual phenomenon including multiple behavioral tests of trichromaticity and color opponency. Data on the combined color/space properties of high order visual neurons in the bee brain is however… read more here.
Keywords: field; brain; neurons anterior; optic tract ... See more keywords
Bilateral Optic Tract Hyperintensity due to Pituitary Apoplexy
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine"
DOI: 10.2169/internalmedicine.1515-18
Abstract: A 51-year-old man was admitted due to sudden headache, fever, and vomiting. A neurologic examination revealed neck stiffness, partial bitemporal hemianopsia, left ptosis, and ophthalmoplegia. Axial computed tomography and sagittal T1-weighted magnetic resonance imaging (MRI)… read more here.
Keywords: tract hyperintensity; bilateral optic; optic tracts; hyperintensity ... See more keywords
Alterations of optic tract and retinal structure in patients after thalamic stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.942438
Abstract: Objectives To investigate the association between degeneration of retinal structure and shrinkage of the optic tract in patients after thalamic stroke. Materials and methods Patients with unilateral thalamic stroke were included. Structural magnetic resonance imaging… read more here.
Keywords: thalamic stroke; patients thalamic; retinal structure; prnfl ... See more keywords