Utility and optimal dose of nicorandil for physiological assessment of the femoropopliteal artery
Sign Up to like & getrecommendations! Published in 2024 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.30976
Abstract: Nicorandil is widely used as a vasodilator for the physiological assessment of coronary arteries because of its usefulness and safety; however, there are no data on its use in peripheral arteries. read more here.
Keywords: nicorandil physiological; physiological assessment; assessment; optimal dose ... See more keywords
Optimal dose escalation methods using deep reinforcement learning in phase I oncology trials.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2023.2170402
Abstract: In phase I trials of a novel anticancer drug, one of the most important objectives is to identify the maximum tolerated dose (MTD). To this end, a number of methods have been proposed and evaluated… read more here.
Keywords: oncology; optimal dose; reinforcement learning; deep reinforcement ... See more keywords
Optimal dose of meropenem for the treatment of neonatal sepsis: Dosing guideline variations and clinical practice deviations
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15308
Abstract: Meropenem is increasingly used to treat neonatal sepsis. There are several guidelines recommending different dosing regimens of meropenem in neonates. Furthermore, deviations from these guidelines regularly occur in daily clinical practice. Therefore, the current study… read more here.
Keywords: optimal dose; practice; dose meropenem; neonatal sepsis ... See more keywords
Phase I/II Study of Erlotinib to Determine the Optimal Dose in Patients With Non‐Small Cell Lung Cancer Harboring Only EGFR Mutations
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Science"
DOI: 10.1111/cts.12796
Abstract: The recommended daily dose of erlotinib was determined for patients with all types of non‐small cell lung cancer (NSCLC). We determined the optimal dose (OD) in patients with NSCLC harboring only epidermal growth factor receptor… read more here.
Keywords: non small; optimal dose; study; cell lung ... See more keywords
The Optimal Dose, Efficacy and Safety of Tranexamic Acid and Epsilon‐Aminocaproic Acid to Reduce Bleeding in TKA: A Systematic Review and Bayesian Network Meta‐analysis
Sign Up to like & getrecommendations! Published in 2023 at "Orthopaedic Surgery"
DOI: 10.1111/os.13678
Abstract: The optimal dose and efficacy of tranexamic acid (TXA) and epsilon‐aminocaproic acid (EACA) in total knee arthroplasty (TKA) were under controversial, and we aimed to make comparisons between different doses of TXA and EACA in… read more here.
Keywords: optimal dose; dose efficacy; aminocaproic acid; acid ... See more keywords
Optimal dose of succinylcholine for laryngeal mask airway insertion: systematic review, meta-analysis and metaregression of randomised control trials
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Open"
DOI: 10.1136/bmjopen-2016-014274
Abstract: Objectives To evaluate the optimal dose of succinylcholine for laryngeal mask airway (LMA) insertion and all related morbidities. Design Systematic review, meta-analysis and metaregression of randomised controlled trials (RCTs). Data source and study eligibility criteria… read more here.
Keywords: insertion; analysis; dose succinylcholine; lma insertion ... See more keywords
Abstract Fri114: Cardio-protective effect on myocardial mitochondrial damage with optimal dose leptin administration in the ischemic heart failure rat model
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.fri114
Abstract: Background: Leptin has emerged as a critical modulator of cardiovascular function, metabolism and structure. Recent research has explored the therapeutic benefits of optimal dose of leptin in the ischemic heart failure (IHF), particularly focusing on… read more here.
Keywords: myocardial mitochondrial; leptin treated; optimal dose; dose leptin ... See more keywords
Optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough suppression: a prospective randomized controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "BMC Anesthesiology"
DOI: 10.1186/s12871-019-0765-z
Abstract: BackgroundTo investigate the optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough (FIC) suppression.MethodsPatients of 180 undergoing elective surgery with general anesthesia, aged 18–65 years, BMI 18.5–30 kg/m2, ASA I or II, were equally randomized into four groups (n = 45)… read more here.
Keywords: dose pretreated; dexmedetomidine fentanyl; group; pretreated dexmedetomidine ... See more keywords
Optimal dose of perineural dexmedetomidine to prolong analgesia after brachial plexus blockade: a systematic review and Meta-analysis of 57 randomized clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "BMC Anesthesiology"
DOI: 10.1186/s12871-021-01452-0
Abstract: Background and Objectives Peripheral injection of dexmedetomidine (DEX) has been widely used in regional anesthesia to prolong the duration of analgesia. However, the optimal perineural dose of DEX is still uncertain. It is important to… read more here.
Keywords: dex; meta analysis; analgesia brachial; brachial plexus ... See more keywords
Optimal dose and duration of iron supplementation for treating iron deficiency anaemia in children and adolescents: A systematic review and meta-analysis
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DOI: 10.1371/journal.pone.0319068
Abstract: Introduction Iron deficiency anaemia (IDA) accounts for nearly two-thirds of all anaemia cases globally. Despite the widespread use of iron supplementation, the optimal dose and duration for treating IDA remain unclear. In this study, we… read more here.
Keywords: iron supplementation; iron; optimal dose; dose duration ... See more keywords
Start up: A French program to support patients with pulmonary arterial hypertension during the adjustment of prostanoids to the individualized optimal dose
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0331008
Abstract: The Start Up program was initiated in patients with pulmonary arterial hypertension (PAH) with the objective to support them in taking their therapies targeting the prostacyclin pathway and determine the individualized optimal dose. This report… read more here.
Keywords: patients pulmonary; support; optimal dose; program ... See more keywords