Optimal dose escalation methods using deep reinforcement learning in phase I oncology trials.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2023.2170402
Abstract: In phase I trials of a novel anticancer drug, one of the most important objectives is to identify the maximum tolerated dose (MTD). To this end, a number of methods have been proposed and evaluated… read more here.
Keywords: oncology; optimal dose; reinforcement learning; deep reinforcement ... See more keywords
Optimal dose of meropenem for the treatment of neonatal sepsis: Dosing guideline variations and clinical practice deviations
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15308
Abstract: Meropenem is increasingly used to treat neonatal sepsis. There are several guidelines recommending different dosing regimens of meropenem in neonates. Furthermore, deviations from these guidelines regularly occur in daily clinical practice. Therefore, the current study… read more here.
Keywords: optimal dose; practice; dose meropenem; neonatal sepsis ... See more keywords
Phase I/II Study of Erlotinib to Determine the Optimal Dose in Patients With Non‐Small Cell Lung Cancer Harboring Only EGFR Mutations
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Science"
DOI: 10.1111/cts.12796
Abstract: The recommended daily dose of erlotinib was determined for patients with all types of non‐small cell lung cancer (NSCLC). We determined the optimal dose (OD) in patients with NSCLC harboring only epidermal growth factor receptor… read more here.
Keywords: non small; optimal dose; study; cell lung ... See more keywords
The Optimal Dose, Efficacy and Safety of Tranexamic Acid and Epsilon‐Aminocaproic Acid to Reduce Bleeding in TKA: A Systematic Review and Bayesian Network Meta‐analysis
Sign Up to like & getrecommendations! Published in 2023 at "Orthopaedic Surgery"
DOI: 10.1111/os.13678
Abstract: The optimal dose and efficacy of tranexamic acid (TXA) and epsilon‐aminocaproic acid (EACA) in total knee arthroplasty (TKA) were under controversial, and we aimed to make comparisons between different doses of TXA and EACA in… read more here.
Keywords: optimal dose; dose efficacy; aminocaproic acid; acid ... See more keywords
Optimal dose of succinylcholine for laryngeal mask airway insertion: systematic review, meta-analysis and metaregression of randomised control trials
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Open"
DOI: 10.1136/bmjopen-2016-014274
Abstract: Objectives To evaluate the optimal dose of succinylcholine for laryngeal mask airway (LMA) insertion and all related morbidities. Design Systematic review, meta-analysis and metaregression of randomised controlled trials (RCTs). Data source and study eligibility criteria… read more here.
Keywords: insertion; analysis; dose succinylcholine; lma insertion ... See more keywords
Optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough suppression: a prospective randomized controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "BMC Anesthesiology"
DOI: 10.1186/s12871-019-0765-z
Abstract: BackgroundTo investigate the optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough (FIC) suppression.MethodsPatients of 180 undergoing elective surgery with general anesthesia, aged 18–65 years, BMI 18.5–30 kg/m2, ASA I or II, were equally randomized into four groups (n = 45)… read more here.
Keywords: dose pretreated; dexmedetomidine fentanyl; group; pretreated dexmedetomidine ... See more keywords
Optimal dose of perineural dexmedetomidine to prolong analgesia after brachial plexus blockade: a systematic review and Meta-analysis of 57 randomized clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "BMC Anesthesiology"
DOI: 10.1186/s12871-021-01452-0
Abstract: Background and Objectives Peripheral injection of dexmedetomidine (DEX) has been widely used in regional anesthesia to prolong the duration of analgesia. However, the optimal perineural dose of DEX is still uncertain. It is important to… read more here.
Keywords: dex; meta analysis; analgesia brachial; brachial plexus ... See more keywords
Barriers against the use of an optimal dose of metformin among patients with T2DM in Thi-Qar province, Iraq
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DOI: 10.25122/jml-2021-0259
Abstract: Diabetes mellitus is a disease with a high burden and prevalence and serious complications. Glycemic control is vital in delaying or preventing complications. Although many people do not take optimal doses, metformin is a cornerstone… read more here.
Keywords: optimal dose; iraq; thi qar; side effects ... See more keywords
The optimal dose of oral tranexamic acid in melasma: A network meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Indian journal of dermatology, venereology and leprology"
DOI: 10.25259/ijdvl_530_2021
Abstract: Background Melasma is a chronic skin condition that adversely impacts quality of life. Although many therapeutic modalities are available there is no single best treatment for melasma. Oral tranexamic acid has been used for the… read more here.
Keywords: optimal dose; oral tranexamic; treatment; melasma ... See more keywords
Investigation of the optimal dose for experimental lipopolysaccharide-induced recognition memory impairment: behavioral and histological studies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative neuroscience"
DOI: 10.31083/j.jin2102049
Abstract: BACKGROUND Lipopolysaccharide (LPS) administration is one of the most commonly used methods for inducing inflammation in animal models. Several animal studies have investigated the effects of acute and chronic peripheral administration of LPS on cognitive… read more here.
Keywords: recognition; optimal dose; impairment behavioral; memory impairment ... See more keywords
The Optimal Dose of Intraoperative Dexmedetomidine for Antiemetic Effects of Post-operative Nausea and Vomiting in Patients Undergoing Elective Thoracic Surgery: A Retrospective Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.891096
Abstract: Background Dexmedetomidine (DEX) administration decreases post-operative nausea and vomiting (PONV), but it is a lack of large-scale retrospective cohort study and is unclear whether there is a dose-relationship and optimal dose for antiemetic effects between… read more here.
Keywords: optimal dose; ponv; dex; cohort ... See more keywords