Discovery and Optimization of a 4-Aminopiperidine Scaffold for Inhibition of Hepatitis C Virus Assembly.
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DOI: 10.1021/acs.jmedchem.1c00696
Abstract: The majority of FDA-approved HCV therapeutics target the viral replicative machinery. An automated high-throughput phenotypic screen identified several small molecules as potent inhibitors of hepatitis C virus replication. Here, we disclose the discovery and optimization… read more here.
Keywords: discovery optimization; optimization aminopiperidine; hepatitis virus; aminopiperidine scaffold ... See more keywords