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Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113000
Abstract: An increasing number of artemisinin (ARS) and its derivatives have been reported for their potential therapeutic value of human cancer. However, their therapeutic potencies are limited owing to their poor pharmacokinetic profiles. Our previous studies…
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Keywords:
optimization biological;
ovarian cancer;
artemisinin;
structural optimization ... See more keywords
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Published in 2021 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2021.113427
Abstract: Abstract Conducting the researches on extraction, optimization, and biological activities of polysaccharides are of great meaning to the development of Platycodon grandiflorus (Jacq.) A. DC. resources. In the present study, the optimum extraction conditions of…
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Keywords:
optimization biological;
extraction;
platycodon grandiflorus;
lmw pgp ... See more keywords
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Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2053525
Abstract: Abstract Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT inhibitors are believed to be a potential platform…
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Keywords:
covalent inhibitors;
covalent;
optimization biological;
design optimization ... See more keywords