Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation.
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DOI: 10.1021/acsmedchemlett.5c00189
Abstract: SARM1 (sterile alpha and Toll/interleukin-1 receptor motif-containing 1) has recently emerged as a promising therapeutic target for several neurodegenerative diseases. Herein, we detail our optimization of SARM1 orthosteric base exchange inhibitors. Early chemical matter was… read more here.
Keywords: sarm1; optimization brain; brain; penetrant sarm1 ... See more keywords