Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties.
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DOI: 10.1016/j.ejmech.2020.112083
Abstract: The EphA2 receptor has been validated in animal models as new target for treating tumors depending on angiogenesis and vasculogenic mimicry. In the present work, we extended our current knowledge on structure-activity relationship (SAR) data… read more here.
Keywords: antagonists based; optimization epha2; based lithocholic; epha2 ... See more keywords