Synergistic and Intelligent Process Optimization: First Results and Open Challenges
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DOI: 10.1021/acs.iecr.0c02032
Abstract: Data science has become an important research topic across scientific disciplines. In Process Systems Engineering, one attempt to create true value from process data is to use it proactively to imp... read more here.
Keywords: intelligent process; first results; synergistic intelligent; process ... See more keywords
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease
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DOI: 10.1021/acs.jmedchem.2c00660
Abstract: Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a high affinity (nM) thiodigalactoside GB0139 which currently is in clinical development… read more here.
Keywords: disease; optimization first; discovery optimization; first highly ... See more keywords
Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
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DOI: 10.1021/acsmedchemlett.2c00160
Abstract: The free fatty acid receptors FFAR1 and FFAR4 are considered promising therapeutic targets for management of metabolic and inflammatory diseases. However, there is a need for entirely novel chemical scaffolds, since many of the highly… read more here.
Keywords: optimization first; first class; dual acting; ffar1 ... See more keywords