Synthesis and Optimization of Nitroxide-Based Inhibitors of Ferroptotic Cell Death in Cancer Cells and Macrophages.
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DOI: 10.1021/acsmedchemlett.1c00561
Abstract: JP4-039 is an alkene peptide isostere that acts as a low-micromolar inhibitor of erastin- and RSL-3-induced ferroptotic cell death in the HT-1080 cell line. In this work, we have developed new synthetic strategies that allow… read more here.
Keywords: cell death; cell; ferroptotic cell; optimization nitroxide ... See more keywords