A mutagenesis study of autoantigen optimization for potential T1D vaccine design
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214430120
Abstract: Significance The exact autoimmune mechanism responsible for causing Type 1 diabetes (T1D) remains unknown, but is thought to be a result of autoimmune activation by some potent self-antigen. A recent work isolated a unique cell… read more here.
Keywords: mutagenesis study; t1d; autoantigen optimization; study autoantigen ... See more keywords
Search for a Minimal Set of Parameters by Assessing the Total Optimization Potential for a Dynamic Model of a Biochemical Network
Sign Up to like & getrecommendations! Published in 2017 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2016.2550451
Abstract: Selecting an efficient small set of adjustable parameters to improve metabolic features of an organism is important for a reduction of implementation costs and risks of unpredicted side effects. In practice, to avoid the analysis… read more here.
Keywords: total optimization; search minimal; minimal set; optimization ... See more keywords