Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.
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DOI: 10.1021/acsmedchemlett.8b00306
Abstract: A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing a subseries showed improvement in their metabolic… read more here.
Keywords: somatostatin receptor; optimization preclinical; preclinical metabolism; receptor subtype ... See more keywords