Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
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DOI: 10.1021/acsmedchemlett.0c00058
Abstract: The action of arginase, a metalloenzyme responsible for the hydrolysis of arginine to urea and ornithine, is hypothesized to suppress immune-cell activity within the tumor microenvironment, and thus its inhibition may constitute a means by… read more here.
Keywords: optimization rationally; discovery optimization; inhibitors human; human arginase ... See more keywords