Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00918
Abstract: The bacterial DNA sliding clamp (SC), or replication processivity factor, is a promising target for the development of novel antibiotics. We report a structure-activity relationship study of a new series of peptides interacting within the… read more here.
Keywords: sliding clamp; based optimization; optimization short; structure based ... See more keywords
Optimization of Short RNA Aptamers for TNBC Cell Targeting
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073511
Abstract: Triple-negative breast cancer (TNBC) is an aggressive cancer with limited targeted therapies. RNA aptamers, suitably chemically modified, work for therapeutic purposes in the same way as antibodies. We recently generated 2′Fluoro-pyrimidines RNA-aptamers that act as… read more here.
Keywords: short rna; aptamers tnbc; tnbc cell; optimization short ... See more keywords