Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
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DOI: 10.1021/acs.jmedchem.8b00929
Abstract: On the basis of our earlier discovery of N1-selective inhibitors, the 150-cavity of influenza virus neuraminidases (NAs) could be further exploited to yield more potent oseltamivir derivatives. Among the synthesized compounds, 15b and 15c were… read more here.
Keywords: substituted oseltamivir; oseltamivir derivatives; derivatives potent; group ... See more keywords