Evaluation and optimization of synthetic routes from dihydroartemisinin to the alkylamino-artemisinins artemiside and artemisone: a test of N-glycosylation methodologies on a lipophilic peroxide
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.04.027
Abstract: Abstract 10-Alkylamino-artemisinins including artemiside and artemisone display enhanced activities against malaria. Earlier, dihydroartemisinin (DHA) TMS ether was converted by trimethylsilyl bromide into the 10-β-bromide that with amine nucleophiles provided the amino-artemisinins. In an attempt to… read more here.
Keywords: alkylamino; alkylamino artemisinins; optimization synthetic; artemiside artemisone ... See more keywords
Optimization of synthetic molecular reporters for a mesenchymal glioblastoma transcriptional program by integer programing
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac488
Abstract: MOTIVATION A recent approach to perform genetic tracing of complex biological problems involves the generation of synthetic DNA probes that specifically mark cells with a phenotype of interest. These synthetic locus control regions (sLCRs), in… read more here.
Keywords: integer; slcr; program; optimization synthetic ... See more keywords