Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.0c01376
Abstract: Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid agonist tetrapeptide H-Dmt-d-Arg-Aba-β-Ala-NH2 (KGOP01) was fused to NT(8-13) analogues. Since the NTS1 receptor has been… read more here.
Keywords: multitarget peptides; affinity; optimized opioid; peptides design ... See more keywords