Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7)
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DOI: 10.1007/s00018-019-03110-8
Abstract: Evolved xCas9(3.7) variant with broad PAM compatibility has been reported in cell lines, while its editing efficiency was site-specific. Here, we show that xCas9(3.7) can recognize a broad PAMs including NGG, NGA, and NGT, in… read more here.
Keywords: base editing; optimized xcas9; base; editing efficiency ... See more keywords