OPTN (optineurin)-mediated selective autophagy prevents neurodegeneration due to herpesvirus infection
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2037223
Abstract: ABSTRACT Very little is known about the mechanisms that restrict neurotropic herpesviruses such as herpes simplex virus-1 (HSV-1) from infecting the central nervous system (CNS) and causing widespread death of neurons. Likewise, HSV-1 is thought… read more here.
Keywords: mediated selective; optineurin mediated; infection; neurodegeneration ... See more keywords
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.50260
Abstract: Mitophagy, the selective removal of damaged mitochondria, is thought to be critical to maintain neuronal homeostasis. Mutations of proteins in the pathway cause neurodegenerative diseases, suggesting defective mitochondrial turnover contributes to neurodegeneration. In primary rat… read more here.
Keywords: optineurin mediated; mitochondria rate; engulfed mitochondria; rate limiting ... See more keywords