Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis
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DOI: 10.1038/s42003-025-07541-x
Abstract: Mitochondrial homeostasis plays a crucial role in the pathogenesis of osteoarthritis (OA), a chronic musculoskeletal disorder characterized by articular cartilage degeneration and chondrocyte apoptosis. However, molecular mechanisms underlying the association between mitophagy and OA remain… read more here.
Keywords: mediated mitophagy; role; optn mediated; progression ... See more keywords
The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D
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DOI: 10.1080/15548627.2022.2055286
Abstract: ABSTRACT Macroautophagy/autophagy is a conserved eukaryotic process to mediate the degradation of cell organelles and protein aggregates, which participates in a variety of cellular responses, including immune signal transduction. KDM4D functions as an important histone… read more here.
Keywords: kdm4d; inhibiting optn; optn mediated; epigenetically regulates ... See more keywords