Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels
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DOI: 10.3390/ijms23126829
Abstract: Mutations in optineurin, a ubiquitin-binding adaptor protein, cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of motor neurons linked to chronic inflammation and protein aggregation. The majority of ALS patients, including those carrying the… read more here.
Keywords: deficiency insufficiency; protein; tdp protein; optn470t microglia ... See more keywords