Optogenetic Control of Non‐Apoptotic Cell Death
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100424
Abstract: Abstract Herein, a set of optogenetic tools (designated LiPOP) that enable photoswitchable necroptosis and pyroptosis in live cells with varying kinetics, is introduced. The LiPOP tools allow reconstruction of the key molecular steps involved in… read more here.
Keywords: non apoptotic; apoptotic cell; cell death; optogenetic control ... See more keywords
Optogenetic Control by Pulsed Illumination
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800030
Abstract: Sensory photoreceptors evoke numerous adaptive responses in nature and serve as light‐gated actuators in optogenetics to enable the spatiotemporally precise, reversible, and noninvasive control of cellular events. The output of optogenetic circuits can often be… read more here.
Keywords: illumination; optogenetic control; pulsed illumination; control pulsed ... See more keywords
Optogenetic Control of Heart Rhythm: Lightly Guiding the Cardiac Pace.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2245-2_13
Abstract: It is well appreciated that, differently from skeletal muscles, the heart contracts independently from neurogenic inputs. However, the speed and force of heartbeats are finely modulated during stresses, emotions, and daily activities, by the autonomic… read more here.
Keywords: optogenetic control; heart; physiology; heart rhythm ... See more keywords
Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26371-z
Abstract: During chemotaxis, neutrophils use cell surface G Protein Coupled Receptors to detect chemoattractant gradients. The downstream signaling system is wired with multiple feedback loops that amplify weak inputs and promote spatial separation of cell front… read more here.
Keywords: actin cdc42; processing; negative signals; optogenetic control ... See more keywords
Optogenetic control of single mRNA spatiotemporal dynamics
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Genetics"
DOI: 10.1038/s41576-020-0219-y
Abstract: A new optogenetic approach called mRNA-LARIAT affords direct optogenetic control of localization and translation of specific mRNAs in living cells. read more here.
Keywords: control single; mrna spatiotemporal; control; single mrna ... See more keywords
Optogenetic control of muscles: potential uses and limitations.
Sign Up to like & getrecommendations! Published in 2023 at "Human gene therapy"
DOI: 10.1089/hum.2022.236
Abstract: Optogenetics is a technique where a cell is transduced with a light-sensitive ion channel. This technique can be used to control muscle cell contraction in conjunction with commonly used viral vectors. However, this technique has… read more here.
Keywords: muscles potential; control; optogenetic control; potential uses ... See more keywords
Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin‐2
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14183
Abstract: Optogenetic control of electromechanical coupling in vascular smooth muscle cells (VSMCs) is emerging as a powerful research tool with potential applications in drug discovery and therapeutics. However, the precise ionic mechanisms involved in this control… read more here.
Keywords: control; ionic mechanisms; control vascular; mechanisms optogenetic ... See more keywords
Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.42475
Abstract: The immune system distinguishes between self and foreign antigens. The kinetic proofreading (KPR) model proposes that T cells discriminate self from foreign ligands by the different ligand binding half-lives to the T cell receptor (TCR).… read more here.
Keywords: tcr; optogenetic control; kinetic proofreading; cell receptor ... See more keywords
Scanned optogenetic control of mammalian somatosensory input to map input-specific behavioral outputs
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.62026
Abstract: Somatosensory stimuli guide and shape behavior, from immediate protective reflexes to longer-term learning and higher-order processes related to pain and touch. However, somatosensory inputs are challenging to control in awake mammals due to the diversity… read more here.
Keywords: input; somatosensory; optogenetic control; scanned optogenetic ... See more keywords
3D optogenetic control of arteriole diameter in vivo
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.72802
Abstract: Modulation of brain arteriole diameter is critical for maintaining cerebral blood pressure and controlling regional hyperemia during neural activity. However, studies of hemodynamic function in health and disease have lacked a method to control arteriole… read more here.
Keywords: optogenetic control; diameter vivo; control arteriole; arteriole diameter ... See more keywords