High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
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DOI: 10.1038/s41467-018-06511-8
Abstract: Optogenetic silencing allows time-resolved functional interrogation of defined neuronal populations. However, the limitations of inhibitory optogenetic tools impose stringent constraints on experimental paradigms. The high light power requirement of light-driven ion pumps and their effects… read more here.
Keywords: optogenetic silencing; ion; anion conducting; soma targeted ... See more keywords
Potassium channel-based optogenetic silencing
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DOI: 10.1038/s41467-018-07038-8
Abstract: Optogenetics enables manipulation of biological processes with light at high spatio-temporal resolution to control the behavior of cells, networks, or even whole animals. In contrast to the performance of excitatory rhodopsins, the effectiveness of inhibitory… read more here.
Keywords: blue light; control; potassium channel; based optogenetic ... See more keywords
Two eARCHT3.0 Lines for Optogenetic Silencing of Dopaminergic and Serotonergic Neurons
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DOI: 10.3389/fncir.2019.00004
Abstract: Dopaminergic and serotonergic neurons modulate and control processes ranging from reward signaling to regulation of motor outputs. Further, dysfunction of these neurons is involved in both degenerative and psychiatric disorders. Elucidating the roles of these… read more here.
Keywords: lines optogenetic; serotonergic neurons; earcht3 lines; optogenetic silencing ... See more keywords