Chronic in vivo optogenetic stimulation modulates neuronal excitability, spine morphology, and Hebbian plasticity in the mouse hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "Hippocampus"
DOI: 10.1002/hipo.23080
Abstract: Prolonged increases in excitation can trigger cell‐wide homeostatic responses in neurons, altering membrane channels, promoting morphological changes, and ultimately reducing synaptic weights. However, how synaptic downscaling interacts with classical forms of Hebbian plasticity is still… read more here.
Keywords: hippocampus; stimulation; optogenetic stimulation; hebbian plasticity ... See more keywords
Holographic optogenetic stimulation with calcium imaging as an all optical tool for cardiac electrophysiology
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202100352
Abstract: All optical approaches to control and read out the electrical activity in a cardiac syncytium can improve our understanding of cardiac electrophysiology. Here, we demonstrate optogenetic stimulation of cardiomyocytes with high spatial precision using light… read more here.
Keywords: cardiac electrophysiology; optogenetic stimulation; activity cardiac; electrical activity ... See more keywords
Optogenetic stimulation of ventral tegmental area dopaminergic neurons in a female rodent model of depression: The effect of different stimulation patterns
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25014
Abstract: Major depressive disorder is one of the most common mental disorders, and more than 300 million of people suffer from depression worldwide. Recent clinical trials indicate that deep brain stimulation of the superolateral medial forebrain… read more here.
Keywords: optogenetic stimulation; long term; depression; effect ... See more keywords
Detection of laser‐associated heating in the brain during simultaneous fMRI and optogenetic stimulation
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29464
Abstract: To calculate temperatures from T2*‐weighted images collected during optogenetic fMRI based on proton resonance frequency (PRF) shift thermometry, to monitor confounding heating effects and determine appropriate light parameters for optogenetic stimulation. read more here.
Keywords: associated heating; heating brain; detection laser; optogenetic stimulation ... See more keywords
Patterned Optogenetic Stimulation Using a DMD Projector.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0830-2_11
Abstract: Optical manipulation is a powerful way to control neural activity in vitro and in vivo with millisecond precision. Patterning of light provides the remarkable ability to simultaneously target spatially segregated neurons from a population. Commercially… read more here.
Keywords: projector; using dmd; stimulation using; patterned optogenetic ... See more keywords
Chronic Optogenetic Stimulation in Freely Moving Rodents.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0830-2_22
Abstract: In vivo optogenetic strategies have been fundamental for the investigation of how neural circuits relate to behavior. While short-term experimental procedures are typically used in such studies, chronic stimulation during behavioral sessions has been largely… read more here.
Keywords: chronic optogenetic; moving rodents; stimulation; freely moving ... See more keywords
Two-Photon Optogenetic Stimulation of Drosophila Neurons.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0830-2_7
Abstract: Optogenetics enables experimental control over neural activity using light. Channelrhodopsin and its variants are typically activated using visible light excitation but can also be activated using infrared two-photon excitation. Two-photon excitation can improve the spatial… read more here.
Keywords: photon optogenetic; two photon; stimulation; stimulation drosophila ... See more keywords
PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers of Medicine"
DOI: 10.1007/s11684-019-0704-x
Abstract: Panic disorder (PD) is an acute paroxysmal anxiety disorder with poorly understood pathophysiology. The dorsal periaqueductal gray (dPAG) is involved in the genesis of PD. However, the downstream neurofunctional changes of the dPAG during panic… read more here.
Keywords: cortex; stimulation; disorder; pet imaging ... See more keywords
Selective optogenetic stimulation of efferent fibers in the vagus nerve of a large mammal
Sign Up to like & getrecommendations! Published in 2021 at "Brain Stimulation"
DOI: 10.1016/j.brs.2020.11.010
Abstract: Background Electrical stimulation applied to individual organs, peripheral nerves, or specific brain regions has been used to treat a range of medical conditions. In cardiovascular disease, autonomic dysfunction contributes to the disease progression and electrical… read more here.
Keywords: stimulation; efferent fibers; vagus nerve; optogenetic stimulation ... See more keywords
Selective optogenetic stimulation of glutamatergic, but not GABAergic, vestibular nuclei neurons induces immediate and reversible postural imbalance in mice
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2021.102085
Abstract: Glutamatergic and GABAergic neurons represent the neural components of the medial vestibular nuclei. We assessed the functional role of glutamatergic and GABAergic neuronal pathways arising from the vestibular nuclei (VN) in the maintenance of gait… read more here.
Keywords: stimulation; mice; optogenetic stimulation; vestibular nuclei ... See more keywords
An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04840-2
Abstract: Serotonin has widespread, but computationally obscure, modulatory effects on learning and cognition. Here, we studied the impact of optogenetic stimulation of dorsal raphe serotonin neurons in mice performing a non-stationary, reward-driven decision-making task. Animals showed… read more here.
Keywords: trial; serotonergic stimulation; learning rates; stimulation ... See more keywords