Characterization of the Orai-Calmodulin Interaction as Potential Mediator of Calcium-Dependent Orai-Channel Inactivation
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1017
Abstract: Calcium is an important second messenger involved in many cellular processes such as cell proliferation, T-cell activation, muscle contraction, egg fertilization, or apoptosis. Calcium entry into non-excitable cells is mainly carried by store-operated Ca2+ release-activated… read more here.
Keywords: calcium; channel inactivation; orai; interaction ... See more keywords
Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aav4663
Abstract: SOCE mediated by ORAI1 affects the metabolism, redox status, and function of enamel cells in teeth. Preventing CRAC’d teeth Store-operated Ca2+ entry (SOCE) through CRAC channels, specifically complexes formed by ORAI Ca2+ channels and STIM… read more here.
Keywords: enamel cells; orai; ca2; soce ... See more keywords
Stim-activated TRPC-ORAI channels in pulmonary hypertension induced by chronic intermittent hypoxia
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DOI: 10.1177/2045894020941484
Abstract: Obstructive sleep apnea (OSA), a breathing disorder featured by chronic intermittent hypoxia (CIH) is associated with pulmonary hypertension (PH). Rodents exposed to CIH develop pulmonary vascular remodeling and PH, but the pathogenic mechanisms are not… read more here.
Keywords: trpc orai; orai; vascular remodeling; cih ... See more keywords
Structures reveal opening of the store-operated calcium channel Orai
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DOI: 10.7554/elife.36758
Abstract: The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER).… read more here.
Keywords: store operated; structures reveal; orai; operated calcium ... See more keywords