Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03933-4
Abstract: Graphic abstract The calcium release-activated calcium (CRAC) channel consists of STIM1, a Ca2+ sensor in the endoplasmic reticulum (ER), and Orai1, the Ca2+ ion channel in the plasma membrane. Ca2+ store depletion triggers conformational changes… read more here.
Keywords: orai1; stim1; ca2; activation ... See more keywords
Sequential Steps of CRAC Channel Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.025
Abstract: Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. How STIM1 binds and activates ORAI1 remains poorly understood. Using electrophysiological, optical,… read more here.
Keywords: orai1; steps crac; crac channel; sequential steps ... See more keywords
Regulation of neuropathic pain by microglial Orai1 channels
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.09.02.506250
Abstract: Microglia are important mediators of neuroinflammation that underlies neuropathic pain. However, the molecular checkpoints controlling microglial reactivity are not well-understood. We investigated the role of Orai1 channels for microglia-mediated neuroinflammation following nerve injury and find… read more here.
Keywords: regulation neuropathic; orai1; orai1 channels; neuropathic pain ... See more keywords
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.321041
Abstract: Background: Pulmonary arterial hypertension (PAH) is characterized by progressive distal pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure. Exacerbated intracellular calcium (Ca2+) signaling contributes to abnormalities in PA smooth muscle cells (PASMCs),… read more here.
Keywords: hpasmcs; arterial hypertension; orai1; pulmonary arterial ... See more keywords
Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263303
Abstract: The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether… read more here.
Keywords: association host; orai1; host genetic; covid fatality ... See more keywords
Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0278613
Abstract: Despite exhibiting cardiotoxicity, doxorubicin (DOX) is widely used for cancer treatments. Cardiac fibroblasts (CFs) are important in the pathogenesis of heart failure. This necessitates the study of the effect of DOX on CFs. The impairment… read more here.
Keywords: apoptosis; cardiac fibroblasts; dox; dox induced ... See more keywords
SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15306
Abstract: Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway smooth… read more here.
Keywords: ca2; orai1; ca2 channel; splunc1 ... See more keywords
A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.82281
Abstract: Ca2+ release-activated Ca2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca2+ sensor. A hallmark of CRAC channels is fast Ca2+-dependent inactivation (CDI) which provides… read more here.
Keywords: orai1; human orai1; inactivation orai1; cdi ... See more keywords