Role of regional absorption and gastrointestinal motility on variability in oral absorption of a model drug
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.04.026
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Variability in oral absorption in pre‐clinical species makes human dose projection challenging. In this study, we investigated the mechanistic basis of variability in oral absorption of a model… read more here.
Keywords: absorption; oral absorption; drug; regional absorption ... See more keywords
Size effect on oral absorption in polymer-functionalized mesoporous carbon nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2017.09.088
Abstract: In this manuscript, the effect of the particle size of polymer-functionalized mesoporous carbon (MPP) nanoparticles on enhancing oral absorption of a water-insoluble drug is first investigated. The insoluble drug, fenofibrate (Fen), was selected as the… read more here.
Keywords: mpp nanoparticles; size; oral absorption; mesoporous carbon ... See more keywords
Mechanisms for oral absorption enhancement of drugs by nanocrystals
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.101607
Abstract: Abstract Currently, numerous new compounds suffer from poor water solubility, hindering their oral absorption from the gastrointestinal tract and thereby limiting their clinical application. Nanocrystal technology, with more than 10 products on the market, is… read more here.
Keywords: absorption; gastrointestinal tract; absorption enhancement; bioavailability ... See more keywords
Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired Gastric Motility.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.05.023
Abstract: Meloxicam (MEL) shows a slow onset of action in severe pain patients on account of delayed gastric motility. This study aimed to develop an amorphous solid dispersion (ASD) of MEL to achieve rapid oral absorption… read more here.
Keywords: absorption; asd mel; oral absorption; mel ... See more keywords
Mechanistic Oral Absorption Modeling of Halofantrine: Exploring the Role of Intestinal Lymphatic Transport.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.12.023
Abstract: Absorption via the intestinal lymphatic system is known to be important for some highly lipophilic compounds, and can be associated with unique pharmacokinetic properties due to evasion of hepatic first-pass metabolism. This work aimed to… read more here.
Keywords: absorption; oral absorption; model; lymphatic transport ... See more keywords
Utilization of Gastrointestinal Simulator, an in Vivo Predictive Dissolution Methodology, Coupled with Computational Approach To Forecast Oral Absorption of Dipyridamole.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.6b01063
Abstract: Weakly basic drugs exhibit a pH-dependent dissolution profile in the gastrointestinal (GI) tract, which makes it difficult to predict their oral absorption profile. The aim of this study was to investigate the utility of the… read more here.
Keywords: methodology; vivo; gastrointestinal simulator; oral absorption ... See more keywords
Slowing down lipolysis significantly enhances the oral absorption of intact solid lipid nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm00873j
Abstract: Only a limited amount of orally administered lipid nanoparticles are absorbed as intact particles due to lipolysis by lipases in the gastrointestinal tract. It is hypothesized that by counteracting lipolysis, more particles will survive gastrointestinal… read more here.
Keywords: absorption intact; oral absorption; slns; lipolysis ... See more keywords
Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2118399
Abstract: Abstract The lipophilicity of a peptide drug can be considerably increased by hydrophobic ion pairing with amphiphilic counterions for successful incorporation into lipid-based formulations. Herein, to enhance the oral absorption of insulin (INS), a self-microemulsifying… read more here.
Keywords: ion pairing; hydrophobic ion; drug delivery; oral absorption ... See more keywords
Multi-functional chitosan copolymer modified nanocrystals as oral andrographolide delivery systems for enhanced bioavailability and anti-inflammatory efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2149894
Abstract: Abstract Modifying nanocrystals with functional materials have been common strategy to enlarge the enhancing ability on oral absorption via nanocrystals; however, whether the functional materials have played their full enhancing ability in oral absorption is… read more here.
Keywords: absorption; sds tpgs; copolymer; oral absorption ... See more keywords
Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2149896
Abstract: Abstract Atorvastatin (ATV) has attracted considerable attention as a potential therapeutic agent for cancer because it inhibits cancer cell proliferation by suppressing the mevalonate pathway. However, because of its low oral absorption, high doses of… read more here.
Keywords: atv; transporter; multivalent intestinal; intestinal transporter ... See more keywords
Factors determining the oral absorption and systemic disposition of zeaxanthin in rats: in vitro, in situ, and in vivo evaluations
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2143534
Abstract: Abstract Context Zeaxanthin is a yellow‑coloured dietary carotenoid widely recognized as an essential component of the macula. It exerts blue light filtering and antioxidant activities, offering eye health and vision benefits. Objective This study explores… read more here.
Keywords: zeaxanthin; zeaxanthin rats; oral absorption; absorption ... See more keywords