The Oral Bioavailability and Effect of Various Gastric Conditions on the Pharmacokinetics of Dersimelagon in Healthy Adult Volunteers
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DOI: 10.1002/cpdd.1235
Abstract: Dersimelagon is a novel orally administered selective agonist for melanocortin receptor 1 being investigated for the treatment of erythropoietic protoporphyria, X‐linked protoporphyria, and diffuse cutaneous systemic sclerosis. In this open‐label, multicenter, randomized, two‐cohort, sequential crossover… read more here.
Keywords: oral bioavailability; various gastric; bioavailability; effect various ... See more keywords
Oral Bioavailability and Pharmacokinetics of Nonanimal Chondroitin Sulfate and Its Constituents in Healthy Male Volunteers
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DOI: 10.1002/cpdd.587
Abstract: The pharmacokinetic profile of a new 800‐mg tablet of nonanimal chondroitin sulfate (CS) (Mythocondro®, 800‐mg tablets, Gnosis S.p.A., Italy) was investigated vs an animal CS in healthy volunteers for a total period of 48 hours.… read more here.
Keywords: oral bioavailability; charge density; nonanimal chondroitin; chondroitin sulfate ... See more keywords
Investigation of the factors responsible for the low oral bioavailability of alizarin using a sensitive LC‐MS/MS method: In vitro, in situ, and in vivo evaluations
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DOI: 10.1002/ddr.22047
Abstract: Alizarin (1,2‐dihydroxyanthraquinone) is an anthraquinone reddish dye widely used for painting and textile dyeing. As the biological activity of alizarin has recently attracted increasing attention from researchers, its therapeutic potential as complementary and alternative medicine… read more here.
Keywords: oral bioavailability; alizarin; alizarin using; method ... See more keywords
Enhanced Oral Bioavailability of Diltiazem by the Influence of Gallic Acid and Ellagic Acid in Male Wistar Rats: Involvement of CYP3A and P‐gp Inhibition
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DOI: 10.1002/ptr.5873
Abstract: The oral bioavailability of diltiazem is very low due to rapid first pass metabolism in liver and intestine. The purpose of the study was to investigate the effect of gallic acid and ellagic acid on… read more here.
Keywords: ellagic acid; oral bioavailability; bioavailability diltiazem; diltiazem ... See more keywords
Impact of water hardness on oxytetracycline oral bioavailability in fed and fasted piglets
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DOI: 10.1002/vms3.185
Abstract: Abstract Water hardness is a critical factor that affects oxytetracycline dissolution by chelation with cations. These interactions may lead to impaired dosing and consequently decrease absorption. Moreover, feed present in gastrointestinal tract may interact with… read more here.
Keywords: oral bioavailability; water; bioavailability; fed fasted ... See more keywords
Organogel Nanoparticles as a New Way to Improve Oral Bioavailability of Poorly Soluble Compounds
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DOI: 10.1007/s11095-020-02808-w
Abstract: The aim of the study was to evaluate organogel nanoparticles as a lipophilic vehicle to increase the oral bioavailability of poorly soluble compounds. Efavirenz (EFV), a Biopharmaceutical Classification System (BCS) Class II, was used as… read more here.
Keywords: oral bioavailability; poorly soluble; bioavailability; bioavailability poorly ... See more keywords
Age-and Region-Dependent Disposition of Raloxifene in Rats.
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DOI: 10.1007/s11095-021-03084-y
Abstract: PURPOSE Raloxifene undergoes extensive glucuronidation in the gastrointestinal (GI) tract and the liver. However, the impact of age on raloxifene disposition has never been studied. The purpose of this paper is to determine glucuronidation and… read more here.
Keywords: oral bioavailability; week; disposition; age ... See more keywords
Lyophilized Nanosuspensions for Oral Bioavailability Improvement of Insoluble Drugs: Preparation, Characterization, and Pharmacokinetic Studies
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DOI: 10.1007/s12247-017-9287-8
Abstract: PurposeWe describe here a novel lyophilized nanosuspension technology in order to improve the dissolution rate and oral bioavailability of the insoluble drug P2X7 receptor antagonist (PRA), which is an effective antagonist to P2X7 receptor for… read more here.
Keywords: oral bioavailability; bioavailability; drug; pra lns ... See more keywords
Methotrexate-Loaded Nanomixed Micelles: Formulation, Characterization, Bioavailability, Safety, and In Vitro Anticancer Study
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DOI: 10.1007/s12247-018-9314-4
Abstract: PurposeMethotrexate (MTX), a potent anticancer drug, shows low oral bioavailability due to its low aqueous solubility and permeability. Moreover, its multidrug resistance (MDR) in cancer and toxic effects restricts its clinical applications. The aim of… read more here.
Keywords: oral bioavailability; mtx pgmm; bioavailability; study ... See more keywords
Formulation development of linagliptin solid lipid nanoparticles for oral bioavailability enhancement: role of P-gp inhibition
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DOI: 10.1007/s13346-020-00839-9
Abstract: Linagliptin (LGP), a novel anti-diabetic drug, is a DPP-4 inhibitor used in the treatment of type II diabetes. One of the major disadvantages of LGP is its low oral bioavailability (29.5%) due to first-pass metabolism… read more here.
Keywords: oral bioavailability; bioavailability; lipid nanoparticles; lgp slns ... See more keywords
Oral bioavailability enhancement of &bgr;‐lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion
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DOI: 10.1016/j.ejpb.2017.12.016
Abstract: Graphical abstract Figure. No caption available. Abstract The aim of this paper was to compare the in vitro dissolution and in vivo bioavailability of three solubility enhancement technologies for &bgr;‐lapachone (LPC), a poorly water soluble… read more here.
Keywords: oral bioavailability; solid dispersion; bioavailability; enhancement ... See more keywords