Development of Hillchol®, a low-cost inactivated single strain Hikojima oral cholera vaccine.
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DOI: 10.1016/j.vaccine.2020.10.043
Abstract: Cholera remains an important global health problem with up to 4 million cases and 140,000 deaths annually. Oral cholera vaccines (OCVs) are now a cornerstone of the WHOs "Ending Cholera - A Global Roadmap to… read more here.
Keywords: hillchol; oral cholera; low cost; development hillchol ... See more keywords
Production of putative enhanced oral cholera vaccine strains that express toxin-coregulated pilus
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DOI: 10.1371/journal.pone.0175170
Abstract: The use of whole cell killed (WCK) oral cholera vaccines is an important strategy for cholera prevention in endemic areas. To overcome current vaccine limitations, we engineered strains of V. cholerae to be non-toxigenic and… read more here.
Keywords: production; vaccine; toxin coregulated; oral cholera ... See more keywords
Immunogenicity and waning immunity from the oral cholera vaccine (Shanchol™) in adults residing in Lukanga Swamps of Zambia
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DOI: 10.1371/journal.pone.0262239
Abstract: Introduction In cholera endemic areas, the periodicity of cholera outbreaks remains unpredictable, making it difficult to organize preventive efforts. Lack of data on duration of protection conferred by oral cholera vaccines further makes it difficult… read more here.
Keywords: immunogenicity waning; immunity; oral cholera; cholera ... See more keywords
Killed Whole-Cell Oral Cholera Vaccine Induces CCL20 Secretion by Human Intestinal Epithelial Cells in the Presence of the Short-Chain Fatty Acid, Butyrate
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DOI: 10.3389/fimmu.2018.00055
Abstract: Short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, modulate immune responses in the gut. However, the effect of SCFAs on mucosal vaccine-induced immune cell migration is poorly understood. Here, we investigated whether SCFAs… read more here.
Keywords: secretion; butyrate; oral cholera; ccl20 secretion ... See more keywords