Oral Delivery of Protein Drugs via Lysine Polymer-Based Nanoparticle Platforms.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300311
Abstract: Oral delivery of proteins has opened a new perspective for the treatment of different diseases. However, advances of oral protein formulation are usually hindered by protein susceptibility and suboptimal absorption in the gastrointestinal tract (GIT).… read more here.
Keywords: lys aapeas; delivery protein; oral delivery; lysine ... See more keywords
Oral Delivery of siRNA Using Fluorinated, Small‐Sized Nanocapsules toward Anti‐Inflammation Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206821
Abstract: Oral delivery of small interfering RNA (siRNA) provides a promising paradigm for treating diseases that require regular injections. However, the multiple gastrointestinal (GI) and systemic barriers often lead to inefficient oral absorption and low bioavailability… read more here.
Keywords: anti inflammation; oral delivery; sirna; inflammation treatment ... See more keywords
RNAi-mediated mortality in Southern green stinkbug Nezara viridula by oral delivery of dsRNA.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.6017
Abstract: BACKGROUND The southern green stinkbug, Nezara viridula (Hemiptera: Pentatomidae), is an important emerging polyphagous pest infesting soybean in the United States, Brazil and Argentina. The indiscriminate use of synthetic insecticides to control stinkbugs has limited… read more here.
Keywords: oral delivery; rnai; mortality; delivery dsrna ... See more keywords
Leaf disc-mediated oral delivery of small molecules in the absence of surfactant to the two-spotted spider mite, Tetranychus urticae
Sign Up to like & getrecommendations! Published in 2018 at "Experimental and Applied Acarology"
DOI: 10.1007/s10493-018-0335-y
Abstract: The two-spotted spider mite (TSSM), Tetranychus urticae, is a chelicerate herbivore with a wide host range and strong ability to develop pesticide resistance. Experimental TSSM populations are easy to maintain, and the recent publication of… read more here.
Keywords: oral delivery; leaf discs; two spotted; leaf ... See more keywords
Mucoadhesive versus Mucopenetrating nanoparticles for oral delivery of insulin.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.08.046
Abstract: Mucoadhesive and mucopenetrating nanoparticles are commonly designed to improve mucosal drug delivery efficiency. Herein, in order to better understand the contribution of mucoadhesion and mucopenetration in oral delivery of biomacromolecules, insulin-loaded poly (n-butylcyanoacrylate) nanoparticles (Ins/PBCA… read more here.
Keywords: absorption; insulin; oral delivery; mucopenetrating nanoparticles ... See more keywords
Recent advances in oral delivery of macromolecular drugs and benefits of polymer conjugation
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Colloid and Interface Science"
DOI: 10.1016/j.cocis.2017.07.002
Abstract: Abstract Oral administration of drugs is a two-edged sword – on one hand it is a non-invasive and easy-to-handle administration of drugs, on the other hand macromolecular pharmaceutical compounds cannot easily cross the epithelial barrier… read more here.
Keywords: polymer conjugation; oral delivery; delivery macromolecular; delivery ... See more keywords
Solid self‐nanoemulsifying drug delivery systems for oral delivery of polypeptide‐k: Formulation, optimization, in‐vitro and in‐vivo antidiabetic evaluation
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.08.022
Abstract: &NA; Development of self‐nanoemulsifying drug delivery systems (SNEDDS) of polypeptide‐k (PPK) is reported with the aim to achieve its oral delivery. Box‐Behnken design (BBD) was adopted to develop and optimize the composition of SNEDDS. Oleoyl… read more here.
Keywords: oral delivery; delivery; formulation; drug ... See more keywords
Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.11.004
Abstract: ABSTRACT The use of polymeric nanoparticles as delivery systems is a promising tool to overcome drawbacks related to low aqueous solubility of drugs, which limit their in vivo bioavailability. The aim of this study was… read more here.
Keywords: plga nanoparticles; clz; nps clz; oral delivery ... See more keywords
Sustained-release multiparticulates for oral delivery of a novel peptidic ghrelin agonist: Formulation design and in vitro characterization.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.11.051
Abstract: There is an impetus to provide appropriate sustained release oral delivery vehicles to protect biofunctional peptide loads from gastric degradation in vivo. This study describes the generation of a high load capacity pellet formulation for… read more here.
Keywords: oral delivery; delivery; formulation; sustained release ... See more keywords
Oral delivery of protein-based therapeutics: Gastroprotective strategies, physiological barriers and in vitro permeability prediction.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119488
Abstract: The number of biological molecules emerging as therapeutics is growing exponentially due to their higher specificity and tolerability profiles compared to small molecules. Despite this, their traditionally parenteral delivery often results in poor patient compliance… read more here.
Keywords: oral delivery; protein based; delivery; based therapeutics ... See more keywords
Oral delivery of a therapeutic gene encoding glucagon‐like peptide 1 to treat high fat diet‐induced diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.08.035
Abstract: &NA; The number of people suffering from insulin‐independent type 2 diabetes mellitus (T2DM) is ever increasing on a yearly basis. Current anti‐diabetic medications often result in adverse weight gain and hypoglycemic episodes. Hypoglycemia can be… read more here.
Keywords: fat diet; glucagon like; oral delivery; delivery ... See more keywords