How long does a single oral dose of cannabidiol persist in plasma? Findings from three clinical trials.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3419
Abstract: A growing number of clinical trials (CTs) are investigating the therapeutic potential of cannabidiol (CBD), a non-intoxicating phytocannabinoid found in Cannabis sativa. These CTs often use crossover experimental designs requiring 'washout' (clearance) periods. However, the… read more here.
Keywords: clinical trials; persist plasma; cbd; single oral ... See more keywords
Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04067-3
Abstract: Purpose Fedratinib is an orally administered Janus kinase 2-selective inhibitor that is indicated for the treatment of adult patients with intermediate-2 or high-risk myelofibrosis in the United States. Fedratinib is metabolized by multiple cytochrome P450s… read more here.
Keywords: fedratinib; oral doses; oral dose; dose fedratinib ... See more keywords
Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Therapy"
DOI: 10.1007/s12325-019-00956-z
Abstract: IntroductionTo investigate the absolute bioavailability of esaxerenone and the effects of food on its pharmacokinetics (PK) after a single oral dose in healthy Japanese subjects.MethodsTwenty-four Japanese males aged 20–45 years were randomised to six groups (each… read more here.
Keywords: esaxerenone; oral dose; absolute bioavailability; single oral ... See more keywords
Rilzabrutinib, a reversible covalent Bruton's tyrosine kinase inhibitor: Absorption, metabolism, excretion and absolute bioavailability in healthy participants.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational science"
DOI: 10.1111/cts.13524
Abstract: This single-center, open-label, non-randomized, two-part, phase I study was conducted 1) to evaluate the absolute oral bioavailability of rilzabrutinib 400 mg tablet following an IV microtracer dose of ~100 μg [14C]-rilzabrutinib (~1 μCi) and single… read more here.
Keywords: rilzabrutinib; excretion; oral dose; absolute bioavailability ... See more keywords
Posaconazole oral dose and plasma levels in pediatric hematology‐oncology patients
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DOI: 10.1111/ejh.13017
Abstract: Posaconazole is a triazole with limited pharmacokinetic information in children. This study assessed the correlation between posaconazole oral solution daily dosage/kg/body weight and trough plasma level. read more here.
Keywords: hematology; dose plasma; posaconazole oral; oral dose ... See more keywords
Thorough QT Study To Evaluate the Effect of Zoliflodacin, a Novel Therapeutic for Gonorrhea, on Cardiac Repolarization in Healthy Adults
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01292-21
Abstract: Zoliflodacin is a novel spiropyrimidinetrione antibiotic being developed as single oral dose treatment to address the growing global threat of Neisseria gonorrhoeae. To evaluate the cardiac safety of zoliflodacin, a thorough QT/QTc (TQT) study was… read more here.
Keywords: oral dose; study; zoliflodacin; zoliflodacin novel ... See more keywords
High Resolution Free Triiodothyronine-Thyrotropin (FT3-TSH) Responses to a Single Oral Dose of Liothyronine in Humans: Evidence of Distinct Inter-Individual Differences Unraveled Using an Electrical Network Model.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biological systems"
DOI: 10.1142/s0218339017500073
Abstract: The effects of a single oral dose of liothyronine (L-T3) on thyroid stimulating hormone (TSH) and other related thyroid system parameters are partly understood despite therapeutic use of this hormone over many decades. We characterize… read more here.
Keywords: using electrical; oral dose; model; dose liothyronine ... See more keywords
Safety assessment of the Quercus brantii gall hydroalcoholic extract: Single and repeated oral dose toxicity studies.
Sign Up to like & getrecommendations! Published in 2022 at "Iranian journal of basic medical sciences"
DOI: 10.22038/ijbms.2022.65488.14418
Abstract: Objectives Quercus brantii galls (QBGs) are well-known in Iranian traditional medicine for treating various diseases. The aim of study was to assess the acute and repeated oral toxicity of the hydroalcoholic extract of QBG in… read more here.
Keywords: toxicity; hydroalcoholic extract; quercus brantii; dose toxicity ... See more keywords
Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers
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DOI: 10.3390/nu14194094
Abstract: The present study characterizes the oral pharmacokinetics of D-Pinitol, a natural insulin mimetic inositol, in human healthy volunteers (14 males and 11 females). D-Pinitol absorption was studied in (a) subjects receiving a single oral dose… read more here.
Keywords: healthy volunteers; pinitol; derived syrup; dose pinitol ... See more keywords
Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats
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DOI: 10.3390/plants10061126
Abstract: The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally used to treat many diseases, including cough, cold, asthma,… read more here.
Keywords: glycyrrhiza new; new variety; toxicity; oral dose ... See more keywords
Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys
Sign Up to like & getrecommendations! Published in 2023 at "Toxins"
DOI: 10.3390/toxins15020088
Abstract: Ochratoxin (OTA) is widely present in a wide range of foods and feeds, causing adverse effects on animals and humans. This study aims to explore the toxicokinetics of OTA-contaminated materials on the Dezhou male donkey.… read more here.
Keywords: dezhou male; ota; toxicokinetics single; single oral ... See more keywords