Safety, Tolerability, and Pharmacokinetics of Multiple Repeated Oral Doses of the α2/3/5‐Subtype Selective GABAA‐Positive Allosteric Modulator PF‐06372865 in Healthy Volunteers
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DOI: 10.1002/cpdd.912
Abstract: Multiple‐dose pharmacokinetics (PK) and safety were investigated in this phase 1 study of PF‐06372865, a positive allosteric modulator of α2/3/5 subunit‐containing γ‐aminobutyric acid A receptors (NCT03351751). In 2 cohorts (7‐8 PF‐06372865 and 2 placebo in… read more here.
Keywords: allosteric modulator; oral doses; safety; twice daily ... See more keywords
Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04067-3
Abstract: Purpose Fedratinib is an orally administered Janus kinase 2-selective inhibitor that is indicated for the treatment of adult patients with intermediate-2 or high-risk myelofibrosis in the United States. Fedratinib is metabolized by multiple cytochrome P450s… read more here.
Keywords: fedratinib; oral doses; oral dose; dose fedratinib ... See more keywords
Relationships between the Structure and Severe Drug-Induced Liver Injury for Low, Medium, and High Doses of Drugs.
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DOI: 10.1021/acs.chemrestox.1c00307
Abstract: Assessment of structure-activity relationships (SARs) for predicting severe drug-induced liver injury (DILI) is essential since in vivo and in vitro preclinical methods cannot detect many druglike compounds disrupting liver functions. To date, plenty of SAR… read more here.
Keywords: drug induced; oral doses; dili; severe drug ... See more keywords
The safety and efficacy of low oral doses of cannabidiol: An evaluation of the evidence
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DOI: 10.1111/cts.13425
Abstract: Global interest in the non‐intoxicating cannabis constituent, cannabidiol (CBD), is increasing with claims of therapeutic effects across a diversity of health conditions. At present, there is sufficient clinical trial evidence to support the use of… read more here.
Keywords: oral doses; safety; efficacy; evidence ... See more keywords
Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats
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DOI: 10.1111/jvp.13061
Abstract: Abstract The study was designed to determine the pharmacokinetic profile and bioavailability of a novel pregabalin 50 mg/ml oral solution formulation (Bonqat®, Orion Corporation Orion Pharma) in 6 healthy laboratory cats. The cats received pregabalin as… read more here.
Keywords: oral doses; solution formulation; solution; pregabalin oral ... See more keywords