PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers
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DOI: 10.1002/jcph.794
Abstract: The spleen tyrosine kinase (SYK) regulates immune cell activation in response to engagement of a variety of receptors, making it an intriguing target for the treatment of inflammatory and autoimmune disorders as well as certain… read more here.
Keywords: kinase; inhibition; healthy volunteers; spleen tyrosine ... See more keywords
Expanded Characterization of a Hemi-Body Shielded Göttingen Minipig Model of Radiation-induced Gastrointestinal Injury Incorporating Oral Dosing Procedures
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DOI: 10.1097/hp.0000000000000750
Abstract: Abstract In collaboration with the Biomedical Advanced Research and Development Authority (BARDA), the authors recently conducted a pilot study in a hemi-body shielded model of radiation-induced gastrointestinal (GI) injury in Göttingen minipigs following exposure to… read more here.
Keywords: oral dosing; hemi body; body shielded; model radiation ... See more keywords
Fractionated oral dosing and its effect on cyclophosphamide pharmacokinetics in dogs with high-grade multicentric lymphoma.
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DOI: 10.1111/vco.12856
Abstract: Cyclophosphamide (CP) is an alkylating agent commonly included in multi-drug treatment protocols for canine cancer. As a prodrug, CP requires hepatic metabolism for activation to the intermediate compound 4-hydroxycyclophosphamide (4-OHCP) which then spontaneously forms alkylating… read more here.
Keywords: fractionated oral; first last; last doses; dosing effect ... See more keywords
Pharmacokinetics and Egg Residues of Meloxicam After Multiple Day Oral Dosing in Domestic Chickens
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DOI: 10.1647/22016-227
Abstract: Abstract With increased ownership of backyard poultry, veterinarians must treat these birds appropriately and take into consideration drug withdrawal times for eggs meant for consumption. Few studies have examined the pharmacokinetics or egg residues for… read more here.
Keywords: medicine; pharmacokinetics egg; residues meloxicam; oral dosing ... See more keywords