3D‐Printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201897
Abstract: During the past decades, microdevices have been evaluated as a means to overcome challenges within oral drug delivery, thus improving bioavailability. Fabrication of microdevices is often limited to planar or simple 3D designs. Therefore, this… read more here.
Keywords: enhanced mucoadhesive; oral drug; drug delivery; geometry ... See more keywords
Microscopic Cascading Devices for Boosting Mucus Penetration in Oral Drug Delivery-Micromotors Nesting Inside Microcontainers.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202206330
Abstract: In the case of macromolecules and poorly permeable drugs, oral drug delivery features low bioavailability and low absorption across the intestinal wall. Intestinal absorption can be improved if the drug formulation could be transported close… read more here.
Keywords: oral drug; mms; mucus; drug delivery ... See more keywords
Current approaches in lipid-based nanocarriers for oral drug delivery
Sign Up to like & getrecommendations! Published in 2021 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-021-00908-7
Abstract: Graphical abstract Lipid-based nanocarriers have gained much interest as carriers of drugs with poor oral bioavailability because of their remarkable advantages like low toxicity, affordable scale-up manufacture, strong biocompatibility or high drug loading efficiency. The… read more here.
Keywords: drug delivery; lipid based; oral drug; based nanocarriers ... See more keywords
Sensing technologies and experimental platforms for the characterization of advanced oral drug delivery systems.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.113850
Abstract: Complex and miniaturized oral drug delivery systems are being developed rapidly for targeted, controlled drug release and improved bioavailability. Standard analytical techniques are widely used to characterize i) drug carrier and active pharmaceutical ingredients before… read more here.
Keywords: oral drug; drug delivery; delivery; delivery systems ... See more keywords
Development and structural characterization of a novel nanoemulsion for oral drug delivery
Sign Up to like & getrecommendations! Published in 2020 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2020.124614
Abstract: Abstract The objective of this work has been to develop a template for the design and characterization of dried nanoemulsion (NE) for oral administration of hydrophobic compounds. A rational optimization of the nanosystem using an… read more here.
Keywords: oral drug; drug delivery; drug; nanoemulsion oral ... See more keywords
An animal's sex influences the effects of the excipient PEG 400 on the intestinal P‐gp protein and mRNA levels, which has implications for oral drug absorption
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.04.021
Abstract: &NA; There is a growing body of evidence which suggests that formerly regarded “inert” pharmaceutical excipients have the potential to influence oral drug bioavailability. The solubilizing agent polyethylene glycol 400 (PEG 400), for instance, has… read more here.
Keywords: protein mrna; oral drug; mrna levels; drug ... See more keywords
A biocompatible Zr-based metal-organic framework UiO-66-PDC as an oral drug carrier for pH-response release
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2020.121805
Abstract: Abstract A biocompatible Zr-based metal-organic framework UiO-66-PDC was synthesized basing on 2,5-pyridinedicarboxylic acid as the ligand. Powder X-ray diffraction (PXRD) was used to characterize the structure and estimate the water stability, exhibiting the ideal structure… read more here.
Keywords: oral drug; uio pdc; drug; biocompatible based ... See more keywords
Dissolution Failure of Solid Oral Drug Products in Field Alert Reports.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.01.014
Abstract: From 2005 to 2014, 370 data entries of dissolution failures of solid oral drug products were assessed with respect to the solubility of drug substances, dosage forms [immediate release (IR) vs. modified release (MR)], and… read more here.
Keywords: dissolution failure; oral drug; solid oral; drug products ... See more keywords
Probiotic Spore-Based Oral Drug Delivery System for Enhancing Pancreatic Cancer Chemotherapy by Gut-Pancreas-Axis-Guided Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c03131
Abstract: The chemotherapeutic effectiveness of pancreatic ductal adenocarcinoma (PDAC) is severely hampered by insufficient intratumoral delivery of antitumor drugs. Here, we demonstrate that enhanced pancreatic cancer chemotherapy can be achieved by probiotic spore-based oral drug delivery… read more here.
Keywords: based oral; oral drug; spore based; drug delivery ... See more keywords
Biomimetic and bioinspired strategies for oral drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm01378d
Abstract: Oral drug delivery remains the most preferred approach due to its multiple advantages. Recently there has been increasing interest in the development of advanced vehicles for oral delivery of different therapeutics. Among them, biomimetic and… read more here.
Keywords: oral drug; oral delivery; drug delivery; delivery ... See more keywords
A pH-sensitive and sustained-release oral drug delivery system: the synthesis, characterization, adsorption and release of the xanthan gum-graft-poly(acrylic acid)/GO–DCFP composite hydrogel
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra01012c
Abstract: In this study, graphene oxide (GO) was successfully prepared using the improved Hummers method, and the prepared GO powder was dissolved in distilled water and subjected to ultrasonic stripping. read more here.
Keywords: oral drug; drug delivery; release; sustained release ... See more keywords