Mutations in LRP5 and BMP4 are associated with mesiodens, tooth agenesis, root malformation, and oral exostoses
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14183
Abstract: WNT/β‐catenin and BMP signaling pathways play important roles in the process of tooth development. Dysregulation of WNT/β‐catenin and BMP signaling is implicated in a number of human malformations, including dental anomalies. Whole exome and Sanger… read more here.
Keywords: oral exostoses; agenesis; dental anomalies; mutations lrp5 ... See more keywords
Rare Variants in LRP4 Are Associated with Mesiodens, Root Maldevelopment, and Oral Exostoses in Humans
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12020220
Abstract: Simple Summary Low density lipoprotein receptor-related protein 4 (LRP4; MIM 604270) modulates WNT/β-catenin signaling, through its binding of WNT ligands, and to co-receptors LRP5/6, and WNT inhibitors DKK1, SOSTDC1, and SOST. LRP4 binds to SOSTDC1… read more here.
Keywords: wnt catenin; variants lrp4; oral exostoses; mice ... See more keywords
Heterozygous Variants in FREM2 Are Associated with Mesiodens, Supernumerary Teeth, Oral Exostoses, and Odontomas
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13071214
Abstract: Background: Supernumerary teeth refer to extra teeth that exceed the usual number of dentitions. A mesiodens is a particular form of supernumerary tooth, which is located in the premaxilla region. The objective of the study… read more here.
Keywords: supernumerary teeth; oral exostoses; heterozygous variants; variants frem2 ... See more keywords