Impact of oral gavage technique of drug-containing microcontainers on the gastrointestinal transit and absorption in rats.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121630
Abstract: Oral gavage is the most common way to administer drug formulations orally to rats. Yet, the technique applied and its influence on gastrointestinal (GI) transit receive little attention. This study aims to investigate the impact… read more here.
Keywords: drug; gavage; gastrointestinal transit; oral gavage ... See more keywords
Delivery method matters: omega-3 supplementation by restricted feeding period and oral gavage has a distinct impact on corticosterone secretion and anxious behavior in adolescent rats
Sign Up to like & getrecommendations! Published in 2020 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2020.1733813
Abstract: ABSTRACT Objectives: Oral gavage and time-restricted feeding are common delivery methods for dietary supplementation to rodents. However, the stress associated with selected feeding regimens could represent a confounding variable. In rodents, the adolescence period is… read more here.
Keywords: oral gavage; restricted feeding; anxiety; supplementation ... See more keywords
An oral gavage of lysine elicited early satiation while gavages of lysine, leucine, or isoleucine prolonged satiety in pigs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Animal Science"
DOI: 10.1093/jas/skac361
Abstract: Abstract Excess dietary amino acids (AA) may negatively affect feed intake in pigs. Previous results showed that Lys, Leu, Ile, Phe, and Glu significantly increased gut peptide secretion (i.e., cholecystokinin, glucagon-like peptide 1). However, the… read more here.
Keywords: leu ile; feed intake; gavage; duration ... See more keywords
Differential anxiety-like responses in NOD/ShiLtJ and C57BL/6J mice following experimental autoimmune encephalomyelitis induction and oral gavage
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Animals"
DOI: 10.1177/0023677218756156
Abstract: Oral gavage is commonly used in pre-clinical drug evaluation, but is potentially aversive and may induce behavioral effects independent of compounds under investigation. This study examined the combined effects of repeated oral gavage and disease… read more here.
Keywords: oral gavage; anxiety like; gavage; mice ... See more keywords
Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects
Sign Up to like & getrecommendations! Published in 2022 at "Particle and Fibre Toxicology"
DOI: 10.1186/s12989-022-00459-w
Abstract: Background The oral uptake of nanoparticles is an important route of human exposure and requires solid models for hazard assessment. While the systemic availability is generally low, ingestion may not only affect gastrointestinal tissues but… read more here.
Keywords: gut microbiota; microbiome plasma; plasma; plasma metabolome ... See more keywords
Acute Toxic Effects of Tetrodotoxin in Mice via Intramuscular Injection and Oral Gavage
Sign Up to like & getrecommendations! Published in 2023 at "Toxins"
DOI: 10.3390/toxins15050334
Abstract: Tetrodotoxin (TTX) is a highly fatal marine biotoxin. Constantly increasing intoxications and the lack of specific antitoxic drugs in clinical applications highlight the need for further research into the toxic effects of TTX. Current reports… read more here.
Keywords: acute toxic; ttx; mice; toxic effects ... See more keywords