Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation therapy concurrent with systemic treatment
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DOI: 10.1007/s12094-021-02586-w
Abstract: The objective of this trial was to evaluate the safety and efficacy of melatonin oral gel mouthwashes in the prevention and treatment of oral mucositis (OM) in patients treated with concurrent radiation and systemic treatment… read more here.
Keywords: trial; treatment; oral gel; oral mucositis ... See more keywords
Design of a pH-responsive oral gel formulation based on the matrix systems of gelatin/hydroxypropyl methylcellulose phthalate for controlled drug release.
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DOI: 10.1016/j.ijpharm.2020.120047
Abstract: Extensive efforts have been directed toward developing novel easily digested formulations with desirable controlled-release properties. The present study sought to develop pH-responsive oral gel formulations using combinations of gelatin and enteric polymers for controlled drug… read more here.
Keywords: responsive oral; drug release; oral gel; controlled drug ... See more keywords
Adipose Mesenchymal Stem Cell Metabolites Oral Gel Enhance Pro-Angiogenic Factors Expression, Angiogenesis, and Clinical Outcome of Oral Ulcer Rat Model
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DOI: 10.1055/s-0043-1761192
Abstract: Abstract Objective  Enhancing wound healing capacity is one of the main principles in oral ulcer management. Efficient oral ulcer management will accelerate clinical symptom amelioration and prevent complications. Adipose mesenchymal stem cell metabolites (AdMSCM), a… read more here.
Keywords: clinical outcome; oral ulcer; ulcer rat; oral gel ... See more keywords
Formulation of a Gastroretentive In Situ Oral Gel Containing Metformin HCl Based on DoE
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DOI: 10.3390/pharmaceutics14091777
Abstract: A gastroretentive in situ oral gel containing metformin hydrochloride (Met HCl) was prepared based on sodium alginate (Sod ALG), calcium carbonate, and hydroxyethylcellulose (HEC). The optimal composition of the formulation was explored based on the… read more here.
Keywords: formulation; gastroretentive situ; situ oral; gel containing ... See more keywords
Structural Characterization and Optimization of a Miconazole Oral Gel
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DOI: 10.3390/polym14225011
Abstract: The development of semisolid formulations, gels in particular, has raised the attention of scientists more and more over the last decades. Because of their biocompatibility, hydrophilic nature, and capacity of absorbing large quantities of water,… read more here.
Keywords: optimization miconazole; miconazole oral; gel; characterization optimization ... See more keywords