Chitosan/Sodium Tripolyphosphate Microemulsion Enhanced Oral Insulin Delivery via Intestinal Lymphoid.
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202400520
Abstract: Oral insulin delivery systems are currently being explored as the best alternative to subcutaneous injections, aiming to overcome gastrointestinal barriers and achieve efficient oral insulin delivery. This study presents a microemulsion delivery system that utilizes… read more here.
Keywords: insulin; insulin delivery; chitosan sodium; delivery ... See more keywords
Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-020-05376-1
Abstract: Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age… read more here.
Keywords: insulin; trial; immunotherapy; oral insulin ... See more keywords
Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery
Sign Up to like & getrecommendations! Published in 2024 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-023-01504-7
Abstract: Oral insulin (INS) is predicted to have the most therapeutic advantages in treating diabetes to repress hepatic glucose production through its potential to mimic the endogenous insulin pathway. Many oral insulin delivery systems have been… read more here.
Keywords: double hydroxide; insulin; insulin delivery; delivery ... See more keywords
The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.07.024
Abstract: Abstract Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-fold… read more here.
Keywords: modified nanoparticles; oral insulin; upregulated intestinal; ligand modified ... See more keywords
An overview of oral insulin delivery strategies (OIDS).
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.03.144
Abstract: Despite tremendous efforts, the world continues its fight against the common chronic disease-diabetes. Diabetes is caused by elevated glucose levels in the blood, which can lead to several complications like glaucoma, cataract, kidney failure, diabetic… read more here.
Keywords: route; delivery strategies; insulin; oral insulin ... See more keywords
Muco-Adhesive and Muco-Penetrative Formulations for the Oral Delivery of Insulin
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.3c10305
Abstract: Insulin, a pivotal anabolic hormone, regulates glucose homeostasis by facilitating the conversion of blood glucose to energy or storage. Dysfunction in insulin activity, often associated with pancreatic β cells impairment, leads to hyperglycemia, a hallmark… read more here.
Keywords: insulin; delivery; muco adhesive; adhesive muco ... See more keywords
Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
Sign Up to like & getrecommendations! Published in 2020 at "Nature Nanotechnology"
DOI: 10.1038/s41565-020-0693-6
Abstract: Oral delivery of protein drugs is considered a life-changing solution for patients who require regular needle injections. However, clinical translation of oral protein formulations has been hampered by inefficient penetration of drugs through the intestinal… read more here.
Keywords: protein; insulin; oral insulin; opening tight ... See more keywords
Engineered acetylated inulin nanoparticles for enhanced oral insulin delivery: sustained release, structural stability, and in vivo efficacy
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra03627e
Abstract: Oral insulin administration is limited by enzymatic degradation and poor gastrointestinal absorption. This study aimed to develop a biopolymer-based nanocarrier using acetylated inulin (InAc) to improve the structural stability and oral bioavailability of insulin. Inulin… read more here.
Keywords: insulin; inulin; efficacy; structural stability ... See more keywords
Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2017.1295064
Abstract: Abstract Because of uncomfortable, painful and even deleterious effects of daily injection of insulin, extensive efforts are being made worldwide for developing noninvasive drug delivery systems, especially via the oral route. In this study, we… read more here.
Keywords: insulin; delivery; oral insulin; hydroxyethyl methacrylate ... See more keywords
Oral insulin (ORMD‐0801) in type 2 diabetes mellitus: A dose‐finding 12‐week randomized placebo‐controlled study
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14901
Abstract: To assess the safety and efficacy of multiple daily doses of oral insulin (ORMD‐0801) in subjects with type 2 diabetes (T2DM) over 12 weeks. read more here.
Keywords: insulin ormd; ormd 0801; type diabetes; oral insulin ... See more keywords
Safety and efficacy of an oral insulin (Capsulin) in patients with early‐stage type 2 diabetes: A dose‐ranging phase 2b study
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14922
Abstract: To compare the pharmacodynamic properties of different doses of regular human insulin administered in capsule form twice daily in a randomised twelve‐week open‐label study. read more here.
Keywords: oral insulin; safety efficacy; efficacy oral; insulin capsulin ... See more keywords