Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-020-05376-1
Abstract: Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age… read more here.
Keywords: insulin; trial; immunotherapy; oral insulin ... See more keywords
The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.07.024
Abstract: Abstract Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-fold… read more here.
Keywords: modified nanoparticles; oral insulin; upregulated intestinal; ligand modified ... See more keywords
An overview of oral insulin delivery strategies (OIDS).
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.03.144
Abstract: Despite tremendous efforts, the world continues its fight against the common chronic disease-diabetes. Diabetes is caused by elevated glucose levels in the blood, which can lead to several complications like glaucoma, cataract, kidney failure, diabetic… read more here.
Keywords: route; delivery strategies; insulin; oral insulin ... See more keywords
Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
Sign Up to like & getrecommendations! Published in 2020 at "Nature Nanotechnology"
DOI: 10.1038/s41565-020-0693-6
Abstract: Oral delivery of protein drugs is considered a life-changing solution for patients who require regular needle injections. However, clinical translation of oral protein formulations has been hampered by inefficient penetration of drugs through the intestinal… read more here.
Keywords: protein; insulin; oral insulin; opening tight ... See more keywords
Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2017.1295064
Abstract: Abstract Because of uncomfortable, painful and even deleterious effects of daily injection of insulin, extensive efforts are being made worldwide for developing noninvasive drug delivery systems, especially via the oral route. In this study, we… read more here.
Keywords: insulin; delivery; oral insulin; hydroxyethyl methacrylate ... See more keywords
Oral insulin (ORMD‐0801) in type 2 diabetes mellitus: A dose‐finding 12‐week randomized placebo‐controlled study
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14901
Abstract: To assess the safety and efficacy of multiple daily doses of oral insulin (ORMD‐0801) in subjects with type 2 diabetes (T2DM) over 12 weeks. read more here.
Keywords: insulin ormd; ormd 0801; type diabetes; oral insulin ... See more keywords
Safety and efficacy of an oral insulin (Capsulin) in patients with early‐stage type 2 diabetes: A dose‐ranging phase 2b study
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14922
Abstract: To compare the pharmacodynamic properties of different doses of regular human insulin administered in capsule form twice daily in a randomised twelve‐week open‐label study. read more here.
Keywords: oral insulin; safety efficacy; efficacy oral; insulin capsulin ... See more keywords
Oral insulin improves metabolic parameters in high fat diet fed rats.
Sign Up to like & getrecommendations! Published in 2017 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765201720170040
Abstract: INTRODUCTION/AIM The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential… read more here.
Keywords: fat diet; insulin; rats oral; metabolic parameters ... See more keywords
Recombinant Protease Inhibitor Enhances Oral Insulin Pharmacodynamics in Pigs
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-121-lb
Abstract: Oral insulin delivery is projected to provide both physiologic and technical benefits, and has been the focus of rigorous research efforts in recent years. The ORMD-0801 oral insulin formulation relies on the activities of both… read more here.
Keywords: insulin; protease; oral insulin; formulation ... See more keywords
Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010062
Abstract: Oral delivery of insulin has always been a challenging task due to harsh gut environment involving variable pH and peptidase actions. Currently, no Food and Drug Administration (FDA) approved oral insulin formulation is commercially available,… read more here.
Keywords: oral insulin; hydrogel; spectroscopy; seed ... See more keywords
Efficacy and safety of oral insulin versus placebo for patients with diabetes mellitus: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_1135_20
Abstract: OBJECTIVE: Compliance to insulin injections is poor due to difficulty in subcutaneous administration. Hence, there is a need of an oral formulation of insulin. Oral insulin is currently under investigation. The present analysis aimed to… read more here.
Keywords: oral insulin; placebo; analysis; diabetes mellitus ... See more keywords