A Pooled Population Pharmacokinetic Study of Oral and Intravenous Administration of Clavulanic Acid in Neonates and Infants: Targeting Effective Beta‐Lactamase Inhibition
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3423
Abstract: Data published on the oral clavulanic acid pharmacokinetics in the pediatric population is lacking. This research aimed to describe clavulanic acid disposition following oral and intravenous administration and to provide insights into clavulanic acid exposure… read more here.
Keywords: population pharmacokinetic; exposure; clavulanic acid; acid ... See more keywords
Pharmacokinetics of Milbemycin Oxime in Pekingese Dogs after Single Oral and Intravenous Administration
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DOI: 10.1002/vms3.70312
Abstract: ABSTRACT Objective This study aimed to characterize the pharmacokinetic profiles of milbemycin oxime in Pekingese dogs following a single oral (PO) and intravenous (IV) dose. Six clinically healthy Pekingese dogs, with an average body weight… read more here.
Keywords: milbemycin oxime; pekingese dogs; administration; single oral ... See more keywords
Oral and intravenous transmission of α-synuclein fibrils to mice
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02037-5
Abstract: Parkinson’s disease and related disorders are neuropathologically characterized by cellular deposits of misfolded and aggregated α-synuclein in the CNS. Disease-associated α-synuclein adopts a conformation that causes it to form oligomers and fibrils, which have reduced… read more here.
Keywords: synuclein; challenge; oral intravenous; synuclein fibrils ... See more keywords
Role of kaempferol to increase bioavailability and pharmacokinetics of nifedipine in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(19)30083-4
Abstract: Herein, the purpose of this study is to evaluate the effects of kaempferol on bioavailability and pharmacokinetics of nifedipine and its metabolite dehydronifedipine in rats. The experimental design is based on with or without kaempferol… read more here.
Keywords: bioavailability pharmacokinetics; bioavailability; kaempferol; pharmacokinetics nifedipine ... See more keywords
In Vitro Activity of Tedizolid in Comparison with Other Oral and Intravenous Agents Against a Collection of Community-Acquired Methicillin-Resistant Staphylococcus aureus (2014-2015) in the United States.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2018.0410
Abstract: Tedizolid activity was compared with other agents with oral and intravenous formulations against community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Tedizolid (MIC50/90, 0.12/0.12 mg/L; 100.0% susceptible) was the most potent agent tested against CA-MRSA and subsets from adult… read more here.
Keywords: acquired methicillin; 100 susceptible; resistant staphylococcus; community acquired ... See more keywords
Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures
Sign Up to like & getrecommendations! Published in 2019 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13970
Abstract: BACKGROUND Individuals perceive the effects of alcohol differently, and the variation is commonly used in research assessing the risk for developing an alcohol use disorder. Such research is supported by both oral and intravenous (IV)… read more here.
Keywords: administration; brac; subjective responses; oral intravenous ... See more keywords
Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration
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DOI: 10.1111/jvim.16452
Abstract: Abstract Background Isavuconazole is a triazole antifungal drug that has shown good efficacy in human patients. Absorption and pharmacokinetics have not been evaluated in cats. Objectives To determine the pharmacokinetics of isavuconazole in cats given… read more here.
Keywords: isavuconazole healthy; oral intravenous; administration; healthy cats ... See more keywords
Plasma pharmacokinetics of quinocetone in ducks after oral and intravenous administration
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DOI: 10.1111/jvp.12426
Abstract: Quinocetone (QCT), an antimicrobial growth promoter, is widely used in food-producing animals. However, information about pharmacokinetics (PK) of QCT in ducks still remains unavailable up to now. In this study, QCT and its major metabolites… read more here.
Keywords: quinocetone; administration; oral intravenous; intravenous administration ... See more keywords
Retrospective analysis to compare the efficacy of oral (O) vs. intravenous (IV) etoposide given in combination with carboplatin for small cell lung cancer (SCLC), extensive disease (ED).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e20020
Abstract: e20020Background: Approximately two thirds of patients diagnosed with SCLC will have ED at the time of diagnosis. Response rates to chemotherapy are high but median overall survival for patients tr... read more here.
Keywords: intravenous etoposide; analysis compare; compare efficacy; efficacy oral ... See more keywords
Comparison between oral and intravenous application of tranexamic acid for total hip arthroplasty: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of comparative effectiveness research"
DOI: 10.2217/cer-2018-0120
Abstract: AIM We conducted a meta-analysis to compare the efficacy and safety of oral and intravenous applications of tranexamic acid (TXA) in total hip arthroplasty (THA). MATERIALS & METHODS Electronic databases, including PubMed, Cochrane CENTRAL, ScienceDirect… read more here.
Keywords: tranexamic acid; oral intravenous; hip arthroplasty; total hip ... See more keywords
Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094851
Abstract: The gastrointestinal tract (GIT) is exposed to xenobiotics, including drugs, through both: local (oral) and systemic routes. Despite the advances in drug discovery and in vitro pre-clinical models, there is a lack of appropriate translational… read more here.
Keywords: sodium arsenite; oral intravenous; mimicking oral; intravenous routes ... See more keywords