Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention
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DOI: 10.1158/1940-6207.capr-16-0286
Abstract: Guanylate cyclase C (GUCY2C) is a tumor-suppressing receptor silenced by loss of expression of its luminocrine hormones guanylin and uroguanylin early in colorectal carcinogenesis. This observation suggests oral replacement with a GUCY2C agonist may be… read more here.
Keywords: epithelial cells; colorectum; chemoprevention; oral linaclotide ... See more keywords