Desmopressin oral lyophilisate in young children: new insights in pharmacokinetics and pharmacodynamics
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DOI: 10.1136/archdischild-2019-318225
Abstract: Objective To study the pharmacokinetic (PK)/pharmacodynamic (PD) characteristics of desmopressin (dDAVP) oral lyophilisate in children below the age of 8 years with special emphasis on age-related and size-related differences in bioavailability. Design Open label, non-randomised,… read more here.
Keywords: ddavp lyophilisate; age; lyophilisate young; oral lyophilisate ... See more keywords
Randomised Comparison of a Novel Buprenorphine Oral Lyophilisate versus Existing Buprenorphine Sublingual Tablets in Opioid-Dependent Patients: A First-in-Patient Phase II Randomised Open Label Safety Study
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DOI: 10.1159/000456612
Abstract: Aims: To test the safety of new buprenorphine oral lyophilisate wafer (“bup-lyo”) versus standard sub-lingual buprenorphine (“bup-SL”). Design: Randomised (2:1) open-label study; opioid-dependent subjects; subsequent partial cross-over. Settings: Specialised clinical trials facility and addictions treatment… read more here.
Keywords: bup; buprenorphine oral; bup lyo; oral lyophilisate ... See more keywords