Oral peptide delivery: Translational challenges due to physiological effects
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.08.032
Abstract: Abstract Oral delivery of peptide therapeutics as a convenient alternate to injections has been an area of research for the pharmaceutical scientific community for the last several decades. However, systemic delivery of therapeutic peptides via… read more here.
Keywords: delivery; peptide delivery; variability; oral peptide ... See more keywords
Progress and limitations of oral peptide delivery as a potentially transformative therapy
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2051476
Abstract: ABSTRACT Introduction Numerous formulation technologies have been developed to overcome challenges of oral peptide delivery. Understanding the advantages and limitations of each technology is important for the development of new delivery systems to enable oral… read more here.
Keywords: peptide delivery; oral peptide; permeation enhancer; delivery ... See more keywords
Recent Advances in Oral Peptide or Protein-Based Drug Liposomes
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DOI: 10.3390/ph15091072
Abstract: The high physiology and low toxicity of therapeutic peptides and proteins have made them a hot spot for drug development in recent years. However, their poor oral bioavailability and unstable metabolism make their clinical application… read more here.
Keywords: oral peptide; protein based; peptide protein; drug ... See more keywords
Gastrointestinal Permeation Enhancers for the Development of Oral Peptide Pharmaceuticals
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DOI: 10.3390/ph15121585
Abstract: Recently, two oral-administered peptide pharmaceuticals, semaglutide and octreotide, have been developed and are considered as a breakthrough in peptide and protein drug delivery system development. In 2019, the Food and Drug Administration (FDA) approved an… read more here.
Keywords: oral peptide; development; gastrointestinal permeation; permeation ... See more keywords