Relationship Between Oral Semaglutide Tablet Erosion and Pharmacokinetics: A Pharmacoscintigraphic Study
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DOI: 10.1002/cpdd.938
Abstract: Semaglutide, a glucagon‐like peptide‐1 (GLP‐1) analogue, has been coformulated in a tablet with the absorption enhancer, sodium N‐(8‐[2‐hydroxybenzoyl] amino) caprylate (SNAC). We investigated tablet erosion and the pharmacokinetics of oral semaglutide administered with 2 different… read more here.
Keywords: water; oral semaglutide; tablet erosion; tablet ... See more keywords
Long-Term Cost-Effectiveness Analyses of Empagliflozin Versus Oral Semaglutide, in Addition to Metformin, for the Treatment of Type 2 Diabetes in the UK
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DOI: 10.1007/s13300-020-00883-1
Abstract: International guidelines recommend treatment with a sodium-glucose cotransporter-2 (SGLT-2) inhibitor or glucagon-like peptide-1 (GLP-1) receptor agonist for treatment intensification in type 2 diabetes mellitus (T2DM) patients with progression on metformin. In the randomised, controlled, Peptide… read more here.
Keywords: addition metformin; treatment; oral semaglutide; semaglutide addition ... See more keywords
Once-Daily Oral Semaglutide Versus Injectable GLP-1 RAs in People with Type 2 Diabetes Inadequately Controlled on Basal Insulin: Systematic Review and Network Meta-analysis
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DOI: 10.1007/s13300-021-01034-w
Abstract: The relative efficacy and safety of once-daily oral semaglutide vs. injectable glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in subjects with type 2 diabetes (T2D) inadequately controlled on basal insulin were assessed using network meta-analysis (NMA).… read more here.
Keywords: semaglutide; glp ras; basal insulin; oral semaglutide ... See more keywords
Safety and Pharmacokinetics of Single and Multiple Ascending Doses of the Novel Oral Human GLP-1 Analogue, Oral Semaglutide, in Healthy Subjects and Subjects with Type 2 Diabetes
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DOI: 10.1007/s40262-018-0728-4
Abstract: BackgroundOral semaglutide is a novel tablet containing the human glucagon-like peptide-1 (GLP‑1) analogue semaglutide, co-formulated with the absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). The safety and pharmacokinetics of oral semaglutide were investigated in two… read more here.
Keywords: glp analogue; safety pharmacokinetics; placebo; oral semaglutide ... See more keywords
Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects
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DOI: 10.1007/s40262-019-00756-2
Abstract: BackgroundOral semaglutide is a tablet co-formulation of the human glucagon-like peptide-1 (GLP-1) analog semaglutide with the absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). The absorption of coadministered oral drugs may be altered due to enhancement by SNAC,… read more here.
Keywords: lisinopril warfarin; warfarin digoxin; metformin; oral semaglutide ... See more keywords
Oral Semaglutide: The First-available Noninjectable Glucagon-like Peptide 1 Receptor Agonist.
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DOI: 10.1016/j.clinthera.2020.07.017
Abstract: PURPOSE There are roughly 30 million Americans diagnosed with diabetes mellitus (DM), with nearly 95% of these cases being type 2 (T2)-DM. The American Diabetes Association continues to recommend metformin as the first-line initial treatment… read more here.
Keywords: semaglutide; glucagon like; receptor agonist; peptide receptor ... See more keywords
The long-term cost-effectiveness of oral semaglutide in the Netherlands based on the PIONEER 2, 3 and 4 randomized controlled trials.
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DOI: 10.1016/j.diabres.2021.108759
Abstract: AIMS To assess the long-term cost-effectiveness of novel glucagon-like peptide-1 (GLP-1) analog oral semaglutide versus sodium-glucose cotransporter-2 inhibitor empagliflozin, dipeptidyl peptidase-4 inhibitor sitagliptin and injectable GLP-1 analog liraglutide in the Netherlands, based on the results… read more here.
Keywords: long term; cost; oral semaglutide; cost effectiveness ... See more keywords
Oral semaglutide in type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2019.107520
Abstract: BACKGROUND Previously, the only available glucagon-like peptide-1 receptor agonists (GLP-1 RA) were injectable. Approval of oral semaglutide (Rybelsus®) represents the first orally available GLP-1 RA. OBJECTIVE To review the literature and describe pharmacologic, pharmacokinetic, and… read more here.
Keywords: type diabetes; semaglutide type; oral semaglutide; semaglutide ... See more keywords
Will oral semaglutide be a game-changer in the management of type 2 diabetes in primary care?
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DOI: 10.1016/j.pcd.2020.07.011
Abstract: GLP-1 receptor agonists (GLP-1RAs) are recommended for patients with type 2 diabetes (T2D), particularly those at high cardiovascular risk. Oral semaglutide is the first oral GLP-1RA. In clinical trials, oral semaglutide 14 mg reduced mean… read more here.
Keywords: game changer; primary care; semaglutide game; type diabetes ... See more keywords
Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial
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DOI: 10.1016/s0140-6736(19)31271-1
Abstract: BACKGROUND Glucagon-like peptide-1 (GLP-1) receptor agonists are effective treatments for type 2 diabetes, lowering glycated haemoglobin (HbA1c) and weight, but are currently only approved for use as subcutaneous injections. Oral semaglutide, a novel GLP-1 agonist,… read more here.
Keywords: oral semaglutide; placebo; subcutaneous liraglutide; week ... See more keywords
Oral semaglutide for the treatment of type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2018.1552258
Abstract: ABSTRACT Introduction: Glucagon-like peptide-1 (GLP-1) receptor agonists are highly potent antihyperglycemic drugs that impose low risk of hypoglycemia and also result in body weight reduction. Currently, all approved members of the class require administration by… read more here.
Keywords: treatment type; semaglutide treatment; type diabetes; oral semaglutide ... See more keywords