Acute Oral Toxicity of Nonfluorinated Fire‐Fighting Foams to Northern Bobwhite Quail (Colinus virginianus)
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5398
Abstract: Long‐chain per‐ and poly‐fluoroalkyl substances (PFAS) have been the active ingredients in firefighting foams for more than 50 years. Due to their extreme persistence, regulatory agencies are concerned about their potential adverse environmental and health… read more here.
Keywords: quail; oral toxicity; fighting foams; fire fighting ... See more keywords
Acute and subacute oral toxicity of copper oxide nanoparticles in female albino Wistar rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3760
Abstract: The extensive use of copper oxide nanoparticles (CuO‐NPs) in various industries and their wide range of applications have led to their accumulation in different ecological niches of the environment. This excess exposure raises the concern… read more here.
Keywords: female albino; oxide nanoparticles; toxicity; copper oxide ... See more keywords
Assessment of the 4‐week repeated‐dose oral toxicity and genotoxicity of GHX02
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3902
Abstract: Herbal medicines are widely utilized for disease prevention and health promotion. GHX02 consists of mixtures including Gwaruin (Trichosanthes kirilowii), Haengin (Prunus armeniaca), Hwangryeon (Coptis japonica) and Hwangkeum (Scutellaria baicalensis). It has been purported to have… read more here.
Keywords: study; toxicity; dose oral; repeated dose ... See more keywords
An evaluation of the genotoxicity and 90‐day repeated dose oral toxicity in rats of Porphyridium purpureum
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4665
Abstract: Interest in microalgae products for use in food is increasing, as demands for sustainable and cost‐effective food choices grow due to the escalating global population and increase in climate‐related struggles with agriculture. Toxicological assessments of… read more here.
Keywords: repeated dose; oral toxicity; dose oral; day repeated ... See more keywords
Prebiotic properties, antioxidant activity, and acute oral toxicity of xylooligosaccharides derived enzymatically from corncob
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DOI: 10.1016/j.fbio.2021.100895
Abstract: Abstract In this study, corncob xylooligosaccharides (corncob-XOS) were prepared enzymatically, and their beneficial effects, compared to commercial prebiotics, including fructooligosaccharides (FOS), gentiooligosaccharides (GTO), inulin, isomaltooligosaccharides (IMO), lactulose, and commercial xylooligosaccharides (commercial-XOS), were assessed. The prebiotic… read more here.
Keywords: oral toxicity; corncob xos; acute oral; corncob ... See more keywords
Subchronic oral toxicity evaluation of gold nanoparticles in male and female mice
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06577
Abstract: Gold nanoparticles (AuNPs) are biocompatible nanomaterials with potential application in the food industry. The safety of AuNPs oral consumption remains inconclusive, and information on possible long-term toxicity is limited. The current study aimed to evaluate… read more here.
Keywords: gold nanoparticles; male female; subchronic oral; toxicity ... See more keywords
Safety assessment of vitacoxib: 180‐day chronic oral toxicity studies
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.03.024
Abstract: ABSTRACT Vitacoxib, a selective COX‐2 inhibitor, is approved for the relief of pain and inflammation associated with orthopedic surgery and osteoarthritis in dogs. In the current study, a chronic toxicity research was performed to evaluate… read more here.
Keywords: chronic oral; vitacoxib; 180 day; toxicity ... See more keywords
In Silico Assessment of Acute Oral Toxicity for Mixtures.
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DOI: 10.1021/acs.chemrestox.0c00256
Abstract: While exposure of humans to environmental hazards often occurs with complex chemical mixtures, the majority of existing toxicity data are for single compounds. The Globally Harmonized System of chemical classification (GHS) developed by the Organization… read more here.
Keywords: ghs category; acute oral; toxicity; toxicity data ... See more keywords
Accurate Prediction of Rat Acute Oral Toxicity and Reference Dose for Thousands of Polycyclic Aromatic Hydrocarbon Derivatives Based on Chemometric QSAR and Machine Learning.
Sign Up to like & getrecommendations! Published in 2024 at "Environmental science & technology"
DOI: 10.1021/acs.est.4c03966
Abstract: Acute oral toxicity is currently not available for most polycyclic aromatic hydrocarbons (PAHs), especially their derivatives, because it is cost-prohibitive to experimentally determine all of them. Here, quantitative structure-activity relationship (QSAR) models using machine learning… read more here.
Keywords: acute oral; oral toxicity; polycyclic aromatic; machine learning ... See more keywords
Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1.
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DOI: 10.1080/01480545.2019.1679828
Abstract: Nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) is an emerging therapeutic target for a spectrum of human diseases. NX-13 is a small molecule therapeutic designed to target and activate NLRX1 to induce immunometabolic… read more here.
Keywords: exploratory studies; toxicity pharmacokinetics; pharmacokinetics rodents; toxicity ... See more keywords
Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity
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DOI: 10.1080/10717544.2021.1944398
Abstract: Abstract To prepare glutaraldehyde-based cross-linked medium molecular weight chitosan nanoparticles encapsulated with 5-Fluorouracil (5-FU), to overcome dosing frequency as well as reducing acute oral toxicity and poor bioavailability of the drug. Medium molecular weight chitosan… read more here.
Keywords: chitosan nanoparticles; medium molecular; acute oral; drug ... See more keywords