From allergen to oral vaccine carrier: A new face of ragweed pollen
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.05.003
Abstract: ABSTRACT Oral delivery of vaccines is highly desirable, yet it has met with limited success. Previously we developed allergen‐free pollen grains as a novel approach for oral vaccination. We showed that spores of Lycopodium clavatum… read more here.
Keywords: oral vaccine; ragweed pollen; vaccine; vaccination ... See more keywords
Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal Immunology"
DOI: 10.1038/s41385-018-0036-1
Abstract: Environmental enteric dysfunction (EED) refers to a subclinical disorder of intestinal function common in tropical countries and in settings of poverty and economic disadvantage. The enteropathy that underlies this syndrome is characterized by mucosal inflammation… read more here.
Keywords: oral vaccine; enteric dysfunction; environmental enteric; vaccine ... See more keywords
A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.
Sign Up to like & getrecommendations! Published in 2021 at "Nature microbiology"
DOI: 10.1038/s41564-021-00911-1
Abstract: The ability of gut bacterial pathogens to escape immunity by antigenic variation-particularly via changes to surface-exposed antigens-is a major barrier to immune clearance1. However, not all variants are equally fit in all environments2,3. It should… read more here.
Keywords: induces immunoglobulin; oral vaccine; vaccine induces; antigen ... See more keywords
Yeast display platform technology to prepare oral vaccine against lethal H7N9 virus challenge in mice
Sign Up to like & getrecommendations! Published in 2020 at "Microbial Cell Factories"
DOI: 10.1186/s12934-020-01316-1
Abstract: Background Existing methods for preparing influenza vaccines pose the greatest challenge against highly pandemic avian influenza H7N9 outbreak in the poultry and humans. Exploring a new strategy for manufacturing and delivering a safe and effective… read more here.
Keywords: yeast display; challenge; oral vaccine; h7n9 ... See more keywords
A Systems Biology Approach Identifies B Cell Maturation Antigen (BCMA) as a Biomarker Reflecting Oral Vaccine Induced IgA Antibody Responses in Humans
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.647873
Abstract: Vaccines against enteric diseases could improve global health. Despite this, only a few oral vaccines are currently available for human use. One way to facilitate such vaccine development could be to identify a practical and… read more here.
Keywords: oral vaccine; biomarker; biology; antigen ... See more keywords
Immunological Effects of Recombinant Lactobacillus casei Expressing IHNV G Protein and Rainbow Trout (Oncorhynchus mykiss) Chemokine CK6 as an Oral Vaccine
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.927443
Abstract: IHNV is a virus that infects salmonids and causes serious economic damage to the salmonid farming industry. There is no specific treatment for the disease caused by this pathogen and the main preventive measure is… read more here.
Keywords: oral vaccine; rainbow; rainbow trout; casei ... See more keywords
Engineering a Novel Bivalent Oral Vaccine against Enteric Fever
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063287
Abstract: Enteric fever is a major global healthcare issue caused largely by Salmonella enterica serovars Typhi and Paratyphi A. The objective of this study was to develop a novel, bivalent oral vaccine capable of protecting against… read more here.
Keywords: engineering; oral vaccine; bivalent oral; enteric fever ... See more keywords
Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against Clostridioides difficile
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9121453
Abstract: Mucosal vaccination aims to prevent infection mainly by inducing secretory IgA (sIgA) antibody, which neutralises pathogens and enterotoxins by blocking their attachment to epithelial cells. We previously demonstrated that encapsulated protein antigen CD0873 given orally… read more here.
Keywords: oral vaccine; clostridioides difficile; cd0873; cd0873 liposomes ... See more keywords