Possible Insufficiency of Generic Price Competition to Contain Prices for Orally Administered Anticancer Therapies
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2017.2788
Abstract: Possible Insufficiency of Generic Price Competition to Contain Prices for Orally Administered Anticancer Therapies Generic price competition is viewed as an important way to contain prices and increase patient access to prescription medications.1,2 Following the… read more here.
Keywords: administered anticancer; contain prices; generic price; price competition ... See more keywords
An Orally Administered CeO 2 @Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202004692
Abstract: © 2020 Wiley-VCH GmbH 2004692 (1 of 14) Q. Liu, Prof. Y. Du State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, Jilin 130022, China Q. Liu, Prof.… read more here.
Keywords: prof; key laboratory; chemistry; china ... See more keywords
A phase 1 study of AMG 900, an orally administered pan‐aurora kinase inhibitor, in adult patients with acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24736
Abstract: Aurora kinases are involved in the pathophysiology of several cancers including acute myeloid leukemia (AML). In this phase 1 study, we investigated the safety and efficacy of AMG 900, an orally administered, highly potent, selective,… read more here.
Keywords: myeloid leukemia; amg 900; acute myeloid; phase study ... See more keywords
Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.10.027
Abstract: Inflammatory bowel disease is a chronic inflammation of the gastrointestinal tract with poor understanding of its pathogenesis and no effective cure. The goal of this study was to evaluate the feasibility of orally administered non-degradable… read more here.
Keywords: inflammatory bowel; orally administered; bowel disease; pcq ... See more keywords
Effects of orally administered Augmentin on glutamate transporter 1, cystine-glutamate exchanger expression and ethanol intake in alcohol-preferring rats
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.12.016
Abstract: ABSTRACT Alcohol dependence is associated with deficits in glutamate uptake and impairment of glutamate homeostasis in different brain reward regions. Glutamate transporter subtype 1 (GLT‐1), cystine‐glutamate exchanger (xCT) and glutamate/aspartate transporter (GLAST) are one of… read more here.
Keywords: administered augmentin; alcohol; expression; glutamate ... See more keywords
In vivo tracking of orally-administered particles within the gastrointestinal tract of murine models using multispectral optoacoustic tomography
Sign Up to like & getrecommendations! Published in 2019 at "Photoacoustics"
DOI: 10.1016/j.pacs.2018.11.003
Abstract: While particle carriers have potential to revolutionize disease treatment, using these carriers requires knowledge of spatial and temporal biodistribution. The goal of this study was to track orally administered particle uptake and trafficking through the… read more here.
Keywords: gastrointestinal tract; microscopy; particle uptake; tract ... See more keywords
Predicting the Pharmacokinetics of Orally Administered Drugs across BCS Classes 1-4 by Virtual Bioequivalence Model.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00688
Abstract: To evaluate the influence of solubility and permeability on the pharmacokinetic prediction performance of orally administered drugs using avirtual bioequivalence (VBE) model, a total of 23 orally administered drugs covering Biopharmaceutics Classification System (BCS) classes… read more here.
Keywords: orally administered; administered drugs; error; bioequivalence ... See more keywords
Interaction of drugs with gut microbiota modulators.
Sign Up to like & getrecommendations! Published in 2023 at "Drug metabolism reviews"
DOI: 10.1080/03602532.2023.2197178
Abstract: Orally administered drugs undergo four stages of absorption, distribution, metabolism, and excretion in the body. However, before being absorbed into the body, orally administered drugs contact with gut microbiota, which catalyze their metabolic reactions such… read more here.
Keywords: microbiota modulators; orally administered; microbiota; gut microbiota ... See more keywords
Sauropus brevipes ethanol extract negatively regulates inflammatory responses in vivo and in vitro by targeting Src, Syk and IRAK1
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2020.1866024
Abstract: Abstract Context Sauropus brevipes Müll. Arg. (Phyllanthaceae) has been used as an effective ingredient in a decoction for the treatment of diarrhoea. However, there was no report on its modulatory role in inflammation. Objective This… read more here.
Keywords: administered 200; orally administered; sauropus brevipes; src syk ... See more keywords
Protective effects of orally administered shark compound peptides from Chiloscyllium plagiosum against acute inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13618
Abstract: The anti-inflammatory effects of shark compound peptides (SCP) from Chiloscyllium plagiosum were investigated. Results showed that SCP enhanced the viability of RAW 264.7 macrophages in vitro in a dose-dependent manner. Orally administered SCP exhibited potent… read more here.
Keywords: shark compound; compound peptides; chiloscyllium plagiosum; orally administered ... See more keywords
An orally administered oral pathobiont and commensal have comparable and innocuous systemic effects in germ‐free mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Periodontal Research"
DOI: 10.1111/jre.12593
Abstract: BACKGROUND AND OBJECTIVES We recently proposed a novel mechanism linking periodontitis and systemic diseases, in which orally administered Porphyromonas gingivalis affects gut microbiota composition and subsequently leads to systemic inflammation. However, the mechanism by which… read more here.
Keywords: free mice; systemic effects; gingivalis; germ free ... See more keywords