Bioequivalence of Esaxerenone Conventional Tablet and Orally Disintegrating Tablet: Two Single‐Dose Crossover Studies in Healthy Japanese Men
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DOI: 10.1002/cpdd.1087
Abstract: We assessed the bioequivalence of a single dose of 5‐mg of esaxerenone administered as an orally disintegrating tablet (ODT) with the conventional oral tablet in healthy Japanese men. This single‐center, open‐label, randomized, two‐drug, two‐stage crossover,… read more here.
Keywords: single dose; orally disintegrating; tablet; disintegrating tablet ... See more keywords
Effect of deglutition aids on the inhibitory effect of orally disintegrating tablets of voglibose on the postprandial elevation of blood glucose levels: a case investigating the interaction between xanthan gum and voglibose
Sign Up to like & getrecommendations! Published in 2018 at "Diabetology International"
DOI: 10.1007/s13340-018-0372-0
Abstract: In this study, we first performed a disintegration test of the voglibose orally disintegrating (V-OD) tablet immersed in jelly-wafer (JW, V-ODims/jw) for 10 min and compared it with the disintegration time of V-OD that was not… read more here.
Keywords: orally disintegrating; deglutition; effect; deglutition aids ... See more keywords
Orally disintegrating dosage forms
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DOI: 10.1007/s40005-018-0408-2
Abstract: An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs… read more here.
Keywords: orally disintegrating; disintegrating dosage; dosage forms; disintegrating tablet ... See more keywords
Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame.
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DOI: 10.1016/j.ijpharm.2017.08.100
Abstract: Salt formation has been extensively used to improve drug properties, including solubility, stability and mechanical properties. A sweet salt of metformin with acesulfame, prepared though an anion exchange reaction, showed superior properties over the commercial… read more here.
Keywords: salt formation; orally disintegrating; sweet salt; acesulfame ... See more keywords
Design of a new disintegration test system for the evaluation of orally disintegrating films
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DOI: 10.1016/j.ijpharm.2018.10.049
Abstract: &NA; In the design of the orally disintegrating films (ODFs), it is important to determine the disintegration time (DT) precisely and properly. These films' DTs are usually assessed by a disintegration test defined in the… read more here.
Keywords: orally disintegrating; system; disintegration; disintegration test ... See more keywords
Formulation design of hydroxypropyl cellulose films for use as orally disintegrating dosage forms
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DOI: 10.1016/j.jddst.2018.05.002
Abstract: Abstract Hydroxypropyl cellulose (HPC) is a water-soluble polymer used as a binder during pharmaceutical tableting and granulation. HPC is also known as a base material for pharmaceutical film by virtue of its film formability with… read more here.
Keywords: hydroxypropyl cellulose; orally disintegrating; hpc; film ... See more keywords
Evaluating superdisintegrants for their performance in orally disintegrating tablets containing lysozyme enzyme
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.12.012
Abstract: Abstract Orally disintegrating tablets (ODTs) are gaining importance and popularity due to their numerous advantages. Lysozyme, an enzyme with antibacterial properties, is currently only available as a conventional tablet and syrup. The main aims of… read more here.
Keywords: containing lysozyme; evaluating superdisintegrants; disintegrating tablets; enzyme ... See more keywords
Effect of starch and hydroxypropyl methylcellulose polymers on the properties of orally disintegrating films
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.03.028
Abstract: Abstract Considering the advantages of orally disintegrating films as alternative pharmaceutical dosage forms, the objective of this work was to develop and evaluate different formulations of orally disintegrating films based on pre-gelatinised starch (%S) and… read more here.
Keywords: hydroxypropyl methylcellulose; starch hydroxypropyl; orally disintegrating; disintegrating films ... See more keywords
Evaluation of dissolution techniques for orally disintegrating mini-tablets
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DOI: 10.1016/j.jddst.2020.102191
Abstract: Abstract Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality… read more here.
Keywords: orally disintegrating; dissolution techniques; mini tablets; techniques orally ... See more keywords
Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial
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DOI: 10.1016/s0140-6736(19)31606-x
Abstract: BACKGROUND Rimegepant, a small molecule calcitonin gene-related peptide receptor antagonist, has shown efficacy in the acute treatment of migraine using a standard tablet formulation. The objective of this trial was to compare the efficacy, safety,… read more here.
Keywords: disintegrating tablet; placebo; treatment; migraine ... See more keywords
Development and optimization of levodopa and benzylhydrazine orally disintegrating tablets by direct compression and response surface methodology
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DOI: 10.1080/03639045.2019.1698597
Abstract: Abstract The number of Parkinson’s disease (PD) patients with the advanced phase and motor fluctuations is increasing. The objective of this study is developing levodopa/benzylhydrazine orally disintegrating tablets (L/B ODTs), which would provide greater convenience… read more here.
Keywords: methodology; orally disintegrating; disintegrating tablets; levodopa benzylhydrazine ... See more keywords