Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves’ orbitopathy
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1037-3
Abstract: ObjectiveGraves’ orbitopathy (GO) is initiated by excessive amount of various inflammatory mediators produced by orbital fibroblasts. This study aimed to assess the crucial role of sphingosine-1-phosphate (S1P) in the inflammatory process of GO.MethodsOrbital adipose/connective tissue… read more here.
Keywords: s1p; sphingosine phosphate; inflammatory process; orbital fibroblasts ... See more keywords
Insulin-like growth factor-1 enhances the expression of functional TSH receptor in orbital fibroblasts from thyroid-associated ophthalmopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.151902
Abstract: Thyroid-associated ophthalmopathy (TAO), an autoimmune disease, occurs in approximately 50 % of patients with Graves' hyperthyroidism. Thyroid-stimulating hormone receptor (TSHR) that is expressed in orbital fibroblasts is the autoimmune target in the development of TAO.… read more here.
Keywords: expression functional; tsh; orbital fibroblasts; igf ... See more keywords
Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts
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DOI: 10.1038/s41598-024-83193-x
Abstract: To elucidate the role of IGF1R inhibition in the pathogenesis of Graves’ orbitopathy (GO), the effects of linsitinib (Lins) on a recombinant human TSHR antibody (M22) and IGF1 to activate TSHR and IGF1R of human… read more here.
Keywords: linsitinib m22; orbital fibroblasts; effects linsitinib; igf1 m22 ... See more keywords
Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves' Ophthalmopathy through the Regulation of FoxO3a Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Mediators of Inflammation"
DOI: 10.1155/2021/8888913
Abstract: Graves' ophthalmopathy (GO), which is characterized by orbital tissue inflammation, expansion, and fibrosis, is the ocular manifestation in 25% to 50% of patients with Graves' disease. As the pathology of GO is driven by autoimmune… read more here.
Keywords: graves ophthalmopathy; orbital fibroblasts; cyr61 expression; cultured orbital ... See more keywords
Potential role of IGF-1R in the interaction between orbital fibroblasts and B lymphocytes: an implication for B lymphocyte depletion in the active inflammatory phase of thyroid-associated ophthalmopathy
Sign Up to like & getrecommendations! Published in 2024 at "BMC Immunology"
DOI: 10.1186/s12865-024-00613-3
Abstract: Background Thyroid eye disease (TED) is an inflammatory process involving lymphocyte-mediated immune response and orbital tissue damage. The anti-insulin-like growth factor-1 receptor (IGF-1R) antibodies produced by B lymphocytes are involved in the activation of orbital… read more here.
Keywords: igf; role; culture; orbital fibroblasts ... See more keywords
Simvastatin downregulates adipogenesis in 3T3-L1 preadipocytes and orbital fibroblasts from Graves’ ophthalmopathy patients
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine Connections"
DOI: 10.1530/ec-19-0319
Abstract: Background Smoking is a strong risk factor for the development of Graves’ ophthalmopathy (GO). Immediate early genes (IEGs) are overexpressed in patients with active GO compared to healthy controls. The aim of this study was… read more here.
Keywords: expression; simvastatin; 3t3 preadipocytes; graves ophthalmopathy ... See more keywords
IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.846106
Abstract: Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO). Previous studies have shown that interleukin (IL)-11 plays a pivotal profibrotic role in various inflammatory and autoimmune diseases. However, the expression pattern of… read more here.
Keywords: profibrotic phenotype; orbital connective; associated ophthalmopathy; orbital fibroblasts ... See more keywords
PD-L1 Inhibits T Cell-Induced Cytokines and Hyaluronan Expression via the CD40-CD40L Pathway in Orbital Fibroblasts From Patients With Thyroid Associated Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.849480
Abstract: Thyroid associated ophthalmopathy (TAO), characterized by T cell infiltration and orbital fibroblast activation, is an organ-specific autoimmune disease which is still short of effective and safety therapeutic drugs. The PD-1/PD-L1 pathway has been reported hindering… read more here.
Keywords: cell; associated ophthalmopathy; cd40; expression ... See more keywords
JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts
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DOI: 10.3390/ijms22062952
Abstract: Transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from orbital fibroblasts is known to dominate tissue remodeling and fibrosis in Graves’ ophthalmopathy (GO). However, the signaling pathways through which TGF-β1 activates Graves’ orbital fibroblasts remain unclear. This… read more here.
Keywords: graves orbital; orbital fibroblasts; growth factor; induced myofibroblast ... See more keywords
Therapeutic role of histone deacetylase inhibition in an in vitro model of Graves' orbitopathy
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2024.13342
Abstract: Graves' orbitopathy (GO), a manifestation of Graves' disease, is characterized by orbital fibroblast-induced inflammation, leading to fibrosis or adipogenesis. Histone deacetylase (HDAC) serves a central role in autoimmune diseases and fibrosis. The present study investigated… read more here.
Keywords: graves orbitopathy; histone deacetylase; orbital fibroblasts; role ... See more keywords