Studies on fluid dynamics of the flow field and gas transfer in orbitally shaken tubes
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2375
Abstract: Orbitally shaken cylindrical bioreactors [OrbShake bioreactors (OSRs)] without an impeller or sparger are increasingly being used for the suspension cultivation of mammalian cells. Among small volume OSRs, 50‐mL tubes with a ventilated cap (OSR50), originally… read more here.
Keywords: gas transfer; fluid dynamics; studies fluid; transfer ... See more keywords
Characterizing the fluid dynamics in the flow fields of cylindrical orbitally shaken bioreactors with different geometry sizes
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DOI: 10.1002/elsc.201700170
Abstract: Orbitally shaken bioreactors (OSRs) are commonly used for the cultivation of mammalian cells in suspension. To aid the geometry designing and optimizing of OSRs, we conducted a three‐dimensional computational fluid dynamics (CFD) simulation to characterize… read more here.
Keywords: fluid dynamics; flow fields; geometry; shaken bioreactors ... See more keywords
Orbitally Shaken Single-Use Bioreactor for Animal Cell Cultivation: Fed-Batch and Perfusion Mode.
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DOI: 10.1007/978-1-0716-0191-4_7
Abstract: Increasing the cultivation volume from small to large scale can be a rather complex and challenging process when the method of aeration and mixing is different between scales. Orbitally shaken bioreactors (OSBs) utilize the same… read more here.
Keywords: perfusion; bioreactor; process; fed batch ... See more keywords
Analysis of volumetric mass transfer coefficient (kLa) in small- (250 mL) to large-scale (2500 L) orbitally shaken bioreactors
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DOI: 10.1007/s13205-020-02352-9
Abstract: In this study, the combination of dimensional analysis (DA) and analysis of variance (ANOVA) was used to predict the volumetric mass transfer coefficient (kLa) values under different operating conditions for orbitally shaken bioreactors (OSRs) with… read more here.
Keywords: coefficient kla; volumetric mass; mass transfer; transfer coefficient ... See more keywords