Dynamics of hippocampus and orbitofrontal cortex activity during arousing reactions from sleep: An intracranial electroencephalographic study
Sign Up to like & getrecommendations! Published in 2021 at "Human Brain Mapping"
DOI: 10.1002/hbm.25609
Abstract: Sleep is punctuated by transient elevations of vigilance level called arousals or awakenings depending on their durations. Understanding the dynamics of brain activity modifications during these transitional phases could help to better understand the changes… read more here.
Keywords: cortex; arousing reactions; orbitofrontal cortex; hippocampus orbitofrontal ... See more keywords
Orbitofrontal Cortex: A ‘Non-rewarding’ New Treatment Target in Depression?
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2018.11.057
Abstract: Self-perpetuating activity in lateral orbitofrontal regions has been theorized to sustain the negative thoughts and emotions of depression. A new study demonstrates that disrupting such activity may yield rapid improvements in mood state, pointing the… read more here.
Keywords: treatment; rewarding new; orbitofrontal cortex; cortex non ... See more keywords
Decision Making: How Is Information Represented in Orbitofrontal Cortex?
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2019.11.015
Abstract: Classically, specific orbitofrontal cortex (OFC) neurons are thought to represent attributes of specific decision options. A new model proposes instead that OFC neurons represent whichever option is currently attended. A recent study, however, tests these… read more here.
Keywords: decision; represented orbitofrontal; making information; information represented ... See more keywords
The orbitofrontal cortex is necessary for learning to ignore
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.03.045
Abstract: Animals learn not only what is potentially useful but also what is meaningless and should be disregarded. How this is accomplished is a key but seldom explored question in psychology and neuroscience. Learning to ignore… read more here.
Keywords: latent inhibition; pre exposure; orbitofrontal cortex; learning ignore ... See more keywords
Risk-taking in humans and the medial orbitofrontal cortex reward system
Sign Up to like & getrecommendations! Published in 2022 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2022.118893
Abstract: Risk-taking differs between humans, and is associated with the personality measures of impulsivity and sensation-seeking. To analyse the brain systems involved, self-report risk-taking, resting state functional connectivity, and related behavioral measures were analyzed in 18,740… read more here.
Keywords: risk; risk taking; orbitofrontal cortex; reward ... See more keywords
A selective serotonin reuptake inhibitor ameliorates obsessive–compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108926
Abstract: Perseveration is a characteristic of patients with obsessive-compulsive disorder (OCD). Clinically, neuronal activity in the lateral orbitofrontal cortex (OFC) is increased in OCD patients. Successful treatment with selective serotonin reuptake inhibitors (SSRIs) reduces activity in… read more here.
Keywords: compulsive disorder; obsessive compulsive; orbitofrontal cortex; lateral ofc ... See more keywords
Pubertal hormones mediate sex differences in levels of myelin basic protein in the orbitofrontal cortex of adult rats
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.03.041
Abstract: Previous work from our lab revealed that adult female rats have increased levels of myelin basic protein (MBP), a marker for myelination, in the orbitofrontal cortex (OFC) as compared to adult males. The goal of… read more here.
Keywords: adult; myelin basic; sex; orbitofrontal cortex ... See more keywords
Inferring action-dependent outcome representations depends on anterior but not posterior medial orbitofrontal cortex
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.09.008
Abstract: &NA; Although studies examining orbitofrontal cortex (OFC) often treat it as though it were functionally homogeneous, recent evidence has questioned this assumption. Not only are the various subregions of OFC (lateral, ventral, and medial) hetereogeneous,… read more here.
Keywords: outcome; mofc; orbitofrontal cortex; anterior posterior ... See more keywords
Altered face scanning and arousal after orbitofrontal cortex lesion in adult rhesus monkeys.
Sign Up to like & getrecommendations! Published in 2020 at "Behavioral neuroscience"
DOI: 10.1037/bne0000342
Abstract: To further assess orbitofrontal cortex (OFC) contribution to the processing of socioemotional signals, spontaneous scanning patterns and pupil diameter variations were measured while adult rhesus macaques with either bilateral lesions of OFC areas 11 and… read more here.
Keywords: adult rhesus; orbitofrontal cortex; group;
The orbitofrontal cortex in temporal cognition.
Sign Up to like & getrecommendations! Published in 2021 at "Behavioral neuroscience"
DOI: 10.1037/bne0000430
Abstract: One of the most important factors in decision-making is estimating the value of available options. Subregions of the prefrontal cortex, including the orbitofrontal cortex (OFC), have been deemed essential for this process. Value computations require… read more here.
Keywords: information; time; orbitofrontal cortex; temporal cognition ... See more keywords
To be specific: The role of orbitofrontal cortex in signaling reward identity.
Sign Up to like & getrecommendations! Published in 2021 at "Behavioral neuroscience"
DOI: 10.1037/bne0000455
Abstract: The orbitofrontal cortex (OFC) plays a prominent role in signaling reward expectations. Two important features of rewards are their value (how good they are) and their specific identity (what they are). Whereas research on OFC… read more here.
Keywords: signaling reward; reward identity; orbitofrontal cortex; role ... See more keywords