The influence of high-order chromatin state in the regulation of stem cell fate.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20220763
Abstract: In eukaryotic cells, genomic DNA is hierarchically compacted by histones into chromatin, which is initially assembled by the nucleosome and further folded into orderly and flexible structures that include chromatin fiber, chromatin looping, topologically associated… read more here.
Keywords: high order; cell; order chromatin; stem cell ... See more keywords
Modulation of the high-order chromatin structure by Polycomb complexes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1021658
Abstract: The multi-subunit Polycomb Repressive Complex (PRC) 1 and 2 act, either independently or synergistically, to maintain and enforce a repressive state of the target chromatin, thereby regulating the processes of cell lineage specification and organismal… read more here.
Keywords: structure; high order; order chromatin; chromatin ... See more keywords
Advances in higher-order chromatin architecture: the move towards 4D genome
Sign Up to like & getrecommendations! Published in 2021 at "BMB Reports"
DOI: 10.5483/bmbrep.2021.54.5.035
Abstract: In eukaryotes, the genome is hierarchically packed inside the nucleus, which facilitates physical contact between cis-regulatory elements (CREs), such as enhancers and promoters. Accumulating evidence highlights the critical role of higher-order chromatin structure in precise… read more here.
Keywords: order; chromatin architecture; higher order; order chromatin ... See more keywords