Organocatalytic Strategies for Higher-Order Cycloadditions: A Review of Substrate Activation and Enantiocontrol.
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DOI: 10.1002/tcr.202500231
Abstract: The construction of complex chiral cyclic architectures, ubiquitous in bioactive natural products, represents a perennial pursuit in organic synthesis. Among the myriad of strategies, cycloaddition reactions are unparalleled in their ability to efficiently assemble such… read more here.
Keywords: higher order; order cycloadditions; activation; organocatalytic strategies ... See more keywords
Rh(II) Catalyzed High Order Cycloadditions of 8-Azaheptafulvenes with N-Sulfonyl 1,2,3-Triazloes or α-Oxo Diazocompounds.
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DOI: 10.1021/acs.orglett.6b03542
Abstract: A novel strategy was developed for the application of Rh carbenes generated from readily accessible N-sulfonyl 1,2,3,-triazoles or diazocompouds in the high order cycloadditions, which offered an efficient route to a variety of N-containing medium-sized… read more here.
Keywords: order cycloadditions; catalyzed high; sulfonyl; high order ... See more keywords
Divergent hetero-[8+n] higher order cycloadditions of tropothione and enals catalyzed by N-heterocyclic carbenes.
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DOI: 10.1039/d5cc02536b
Abstract: Divergent asymmetric NHC-catalyzed [8+n] higher-order cycloadditions using tropothione as an electron-poor 8π component were developed. The base-dependent selectivity of the synthetic approach allowed obtaining heterocyclic products bearing either γ- or δ-thiolactone rings with high enantioselectivity.… read more here.
Keywords: divergent hetero; higher order; hetero higher; order cycloadditions ... See more keywords